Source:http://linkedlifedata.com/resource/pubmed/id/11494168
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0020455,
umls-concept:C0020852,
umls-concept:C0021311,
umls-concept:C0024530,
umls-concept:C0032043,
umls-concept:C0032659,
umls-concept:C0238606,
umls-concept:C0240919,
umls-concept:C0348011,
umls-concept:C0442375,
umls-concept:C0445604,
umls-concept:C1705822,
umls-concept:C1858460
|
| pubmed:issue |
5
|
| pubmed:dateCreated |
2001-8-8
|
| pubmed:abstractText |
Two hundred thirteen mother-baby pairs in The Gambia were studied to determine the influence of placental malaria infection and maternal hypergammaglobulinemia on transplacental antibody transfer. Antibody transfer for herpes simplex virus 1 (HSV-1), respiratory syncytial virus (RSV), and varicella-zoster virus (VZV) was significantly reduced by placental malaria infection by 69%, 58%, and 55%, respectively. Maternal hypergammaglobulinemia was associated with a significant reduction in antibody transfer for HSV-1, RSV, VZV, and pneumococcus by 89%, 90%, 91%, and 88%, respectively. In addition, placental malaria infection was associated with a significant reduction in transfer of IgG1, IgG2, and IgG4 (P<.01, P=.01, and P=.03, respectively) but not of IgG3 (P=.59). Maternal hypergammaglobulinemia significantly impaired the transfer of IgG1 and IgG2 (P=.01) but not of IgG3 or IgG4 (P=.62 and P=.59, respectively). Placental malaria infection and maternal hypergammaglobulinemia were associated with reduction in the transplacental transfer of these specific antibodies, IgG1, and IgG2 in this Gambian population.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0022-1899
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
184
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
627-32
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:11494168-Adult,
pubmed-meshheading:11494168-Animals,
pubmed-meshheading:11494168-Antibodies, Bacterial,
pubmed-meshheading:11494168-Antibodies, Viral,
pubmed-meshheading:11494168-Female,
pubmed-meshheading:11494168-Gambia,
pubmed-meshheading:11494168-Humans,
pubmed-meshheading:11494168-Hypergammaglobulinemia,
pubmed-meshheading:11494168-Immunity, Maternally-Acquired,
pubmed-meshheading:11494168-Immunoglobulin G,
pubmed-meshheading:11494168-Infant, Newborn,
pubmed-meshheading:11494168-Malaria, Falciparum,
pubmed-meshheading:11494168-Male,
pubmed-meshheading:11494168-Placenta,
pubmed-meshheading:11494168-Placenta Diseases,
pubmed-meshheading:11494168-Plasmodium falciparum,
pubmed-meshheading:11494168-Pregnancy,
pubmed-meshheading:11494168-Pregnancy Complications, Parasitic
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
The influence of placental malaria infection and maternal hypergammaglobulinemia on transplacental transfer of antibodies and IgG subclasses in a rural West African population.
|
| pubmed:affiliation |
Vaccine Trial Unit, Medical Research Council, Fajara, Banjul, The Gambia, West Africa. okokobrown@hotmail.com
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|