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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2001-8-7
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pubmed:abstractText |
Formation of DNA adducts following conversion of dichloromethane by bacterial dichloromethane dehalogenase/glutathione S-transferase was demonstrated. Adducts included dichloromethane carbon and glutathione sulfur atoms. A reaction with DNA occurred preferentially at guanine bases. Increased DNA degradation in a polA mutant of Methylobacterium dichloromethanicum DM4 grown with dichloromethane confirmed the genotoxicity associated with dichloromethane degradation, suggesting an important role of DNA repair in the metabolism of halogenated, DNA-alkylating compounds by bacteria.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11489877-10350186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11489877-10698764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11489877-10986246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11489877-11018744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11489877-11238968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11489877-8075359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11489877-8132617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11489877-8378332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11489877-8671744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11489877-8706748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11489877-9045797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11489877-9074797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11489877-9435885
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0021-9193
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
183
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5209-12
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
2001
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pubmed:articleTitle |
Dehalogenation of dichloromethane by dichloromethane dehalogenase/glutathione S-transferase leads to formation of DNA adducts.
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pubmed:affiliation |
Institut für Mikrobiologie, ETH Zürich, CH-8092 Zürich, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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