Source:http://linkedlifedata.com/resource/pubmed/id/11486876
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
2001-8-6
|
| pubmed:abstractText |
(-)-2,3:4,6-Di-O-isopropylidene-2-keto-L-gulonic acid [(-)-DIKGA] has been introduced as a chiral counter ion in non-aqueous capillary electrophoresis. High enantioresolutions (R(s)> or =3) were obtained for amines, e.g., pronethalol, labetalol and bambuterol. Methanol containing NaOH and (-)-DIKGA was used as the background electrolyte. The counter ion concentration and the nature of the injection medium were found to affect the chiral separation. Covalent coating of the fused-silica capillary reduced the electro-osmotic flow resulting in improved enantioresolutions.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0021-9673
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
13
|
| pubmed:volume |
922
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
303-11
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| pubmed:dateRevised |
2009-1-15
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| pubmed:meshHeading |
pubmed-meshheading:11486876-Amines,
pubmed-meshheading:11486876-Bicyclo Compounds, Heterocyclic,
pubmed-meshheading:11486876-Electrophoresis, Capillary,
pubmed-meshheading:11486876-Indicators and Reagents,
pubmed-meshheading:11486876-Reproducibility of Results,
pubmed-meshheading:11486876-Stereoisomerism,
pubmed-meshheading:11486876-Sugar Acids
|
| pubmed:year |
2001
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| pubmed:articleTitle |
Non-aqueous capillary electrophoretic separation of enantiomeric amines with (-)-2,3:4,6-di-O-isopropylidene-2-keto-L-gulonic acid as chiral counter ion.
|
| pubmed:affiliation |
Division of Analytical Pharmaceutical Chemistry, Uppsala University, Biomedical Centre, Sweden.
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| pubmed:publicationType |
Journal Article
|