Linked Life Data

11484101

Source:http://linkedlifedata.com/resource/pubmed/id/11484101

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-8-2
pubmed:abstractText
Two hundred and twenty-eight Japanese women, aged 45-69 years, with osteoarthritis of the knee (knee OA) and a body mass index of greater than 26.4 self-selected one of the following interventions: (1) a nonsteroidal anti-inflammatory drug (NSAID) alone (NA group; n = 52), (2) the NSAID with nonweight-bearing exercises (NE; n = 49), (3) the NSAID combined with walking (NW; n = 35), (4) an energy restriction diet plus the NSAID (ND; n = 29), (5) the diet combined with the NSAID and strengthening exercises (NDE; n = 37), or (6) the diet combined with the NSAID and walking (NDW; n = 26). Body weight and lower extremity lean body mass (L-LBM), assessed with segmental bioelectrical impedance, were measured at the outset and at 8 weeks in the six therapy groups. Interval changes in L-LBM and L-LBM per body weight (L-LBM/weight) were compared among the six groups at the conclusion. The Lequesne index can index of severity of osteoarthritis of the knee at the final assessment, compared with that at the initial assessment, was significantly decreased in the NE group, but not in the NW or the NA groups (P = 0.023). There was a significant increase in the L-LBM/weight in the NE group, but not in the NA or NW groups (P = 0.002 between NE and NA; P = 0.019 between NE and NW). There was a significant reduction in the Lequesne index in the NDE group in comparison with the ND and NDW groups (P = 0.0001 between NDE and ND; P = 0.0001 between NDE and NDW). There was a significant increase in L-LBM/weight in the NDE group, but not in the NDW or the ND groups (P = 0.011). Adjunctive therapy with nonweight-bearing lower extremity exercises appears to be more efficacious for prevention of lower extremity loss of muscle mass than adjunctive therapy with walking for obese women with knee OA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0949-2658
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
148-54
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
The effect of energy restriction, walking, and exercise on lower extremity lean body mass in obese women with osteoarthritis of the knee.
pubmed:affiliation
Toda Orthopedic Rheumatology Clinic, 14-1 Toyotsu-cho, Suita, Osaka 564-0051, Japan.
pubmed:publicationType
Journal Article, Clinical Trial