|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0016360,
umls-concept:C0031327,
umls-concept:C0036525,
umls-concept:C0087111,
umls-concept:C0123931,
umls-concept:C0600688,
umls-concept:C1280500,
umls-concept:C1516213,
umls-concept:C1519249,
umls-concept:C1522484,
umls-concept:C1527249
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|
pubmed:issue |
15
|
|
pubmed:dateCreated |
2001-8-1
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|
pubmed:abstractText |
To investigate the sequence effect of irinotecan and a 48-hour infusion of fluorouracil (5-FU) modulated by leucovorin (LV) on the plasma pharmacokinetics of irinotecan and its metabolites, the toxicity profile of this combination, and irinotecan's maximum-tolerated dose (MTD).
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0732-183X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
1
|
|
pubmed:volume |
19
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3456-62
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|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:11481350-Adenocarcinoma,
pubmed-meshheading:11481350-Adult,
pubmed-meshheading:11481350-Aged,
pubmed-meshheading:11481350-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:11481350-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:11481350-Camptothecin,
pubmed-meshheading:11481350-Colorectal Neoplasms,
pubmed-meshheading:11481350-Drug Administration Schedule,
pubmed-meshheading:11481350-Enzyme Inhibitors,
pubmed-meshheading:11481350-Female,
pubmed-meshheading:11481350-Fluorouracil,
pubmed-meshheading:11481350-Humans,
pubmed-meshheading:11481350-Infusions, Intravenous,
pubmed-meshheading:11481350-Leucovorin,
pubmed-meshheading:11481350-Male,
pubmed-meshheading:11481350-Middle Aged,
pubmed-meshheading:11481350-Neoplasm Metastasis
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|
pubmed:year |
2001
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|
pubmed:articleTitle |
Sequence effect of irinotecan and fluorouracil treatment on pharmacokinetics and toxicity in chemotherapy-naive metastatic colorectal cancer patients.
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|
pubmed:affiliation |
Division of Medical Oncology, Department of Oncology, Civil Hospital, Livorno, Italy. a.falcone@do.med.unipi.it
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|
