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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2001-7-26
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pubmed:abstractText |
Recently, we synthesized a nonviral gene vector capable of transfecting cell lines taking advantage of neurotensin (NT) internalization. The vector is NT cross-linked with poly-L-lysine, to which a plasmid DNA was bound to form a complex (NT-polyplex). Nigral dopamine neurons are able to internalize NT, thus representing a target for gene transfer via NT-polyplex. This hypothesis was tested here using reporter genes encoding green fluorescent protein or chloramphenicol acetyl transferase.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1076-1551
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
186-92
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pubmed:dateRevised |
2008-11-20
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pubmed:meshHeading |
pubmed-meshheading:11471555-Animals,
pubmed-meshheading:11471555-Chloramphenicol O-Acetyltransferase,
pubmed-meshheading:11471555-DNA,
pubmed-meshheading:11471555-Dopamine,
pubmed-meshheading:11471555-Fluorescent Antibody Technique,
pubmed-meshheading:11471555-Gene Expression Regulation,
pubmed-meshheading:11471555-Gene Transfer Techniques,
pubmed-meshheading:11471555-Genes, Reporter,
pubmed-meshheading:11471555-Green Fluorescent Proteins,
pubmed-meshheading:11471555-Luminescent Proteins,
pubmed-meshheading:11471555-Male,
pubmed-meshheading:11471555-Neuroglia,
pubmed-meshheading:11471555-Neurons,
pubmed-meshheading:11471555-Pyrazoles,
pubmed-meshheading:11471555-Quinolines,
pubmed-meshheading:11471555-Rats,
pubmed-meshheading:11471555-Rats, Wistar,
pubmed-meshheading:11471555-Receptors, Neurotensin,
pubmed-meshheading:11471555-Substantia Nigra
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pubmed:year |
2001
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pubmed:articleTitle |
In vivo gene transfer to dopamine neurons of rat substantia nigra via the high-affinity neurotensin receptor.
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pubmed:affiliation |
Departamento de Biología Celular, Avanzados del Instituto Politécnico Nacional de México, Mexico.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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