Linked Life Data

11470559

Source:http://linkedlifedata.com/resource/pubmed/id/11470559

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2001-7-25
pubmed:abstractText
The laminar cortical distribution of the [125I]alpha-bungarotoxin, [3H]cytisine and [3H]epibatidine nicotinic acetylcholine receptor ligands was investigated by quantitative autoradiography in autopsy tissue from the cingulate, orbitofrontal and temporal cortices of control and schizophrenia subjects matched for age and smoking history. Different laminar binding patterns were observed for the various nicotinic ligands both in schizophrenic and control brains. [125I]alpha-Bungarotoxin binding was distributed homogeneously across all cortical layers in all three brain regions, with highest binding densities in the cingulate cortex. [3H]Cytisine and [3H]epibatidine binding varied across the cortical ribbon, with high binding in layers I, III, V and VI, within the three cortical regions. A significantly reduced [125I] alpha-bungarotoxin binding (-54%) was observed in the cingulate cortex of schizophrenia subjects, in comparison with normal individuals who smoked tobacco. In the same brain region also a significantly higher [3H]cytisine binding (48-77%) was observed in nearly all layers, except for layer I of the schizophrenia subjects, when compared to normal individuals with a history of tobacco use. No significant changes in [3H]epibatidine binding was observed within the individual cortical layers between control subjects and patients with schizophrenia, but when calculated as a whole region (i.e. measurements performed across the whole cortical ribbon), the temporal cortex showed a significant increase in [3H]epibatidine binding in schizophrenia subjects compared to control subjects. The results suggest opposite changes of the alpha4beta2 and alpha7 nicotinic receptor subtypes in the cingulate cortex of patients with schizophrenia which might reflect involvement of two different nicotinic receptor mechanisms in schizophrenia brain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0891-0618
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
115-26
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11470559-Acetylcholine, pubmed-meshheading:11470559-Aged, pubmed-meshheading:11470559-Bicyclo Compounds, Heterocyclic, pubmed-meshheading:11470559-Binding Sites, pubmed-meshheading:11470559-Brain Chemistry, pubmed-meshheading:11470559-Bungarotoxins, pubmed-meshheading:11470559-Cerebral Cortex, pubmed-meshheading:11470559-Cystine, pubmed-meshheading:11470559-Female, pubmed-meshheading:11470559-Humans, pubmed-meshheading:11470559-Iodine Radioisotopes, pubmed-meshheading:11470559-Ligands, pubmed-meshheading:11470559-Male, pubmed-meshheading:11470559-Middle Aged, pubmed-meshheading:11470559-Neurons, pubmed-meshheading:11470559-Nicotinic Agonists, pubmed-meshheading:11470559-Pyridines, pubmed-meshheading:11470559-Radioligand Assay, pubmed-meshheading:11470559-Receptors, Nicotinic, pubmed-meshheading:11470559-Schizophrenia, pubmed-meshheading:11470559-Tobacco Use Disorder, pubmed-meshheading:11470559-Tritium
pubmed:year
2001
pubmed:articleTitle
Laminar distribution of nicotinic receptor subtypes in cortical regions in schizophrenia.
pubmed:affiliation
Karolinska Institutet, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research (NEUROTEC), Division of Molecular Neuropharmacology, Huddinge University Hospital, B84, S-141 86, Stockholm, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't