|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2001-7-25
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Members of the vancomycin group of glycopeptide antibiotics have an oxidatively crosslinked heptapeptide scaffold decorated at the hydroxyl groups of 4-OH-Phegly4 or beta-OH-Tyr6 with mono- (residue 6) or disaccharides (residue 4). The disaccharide in vancomycin itself is L-vancosamine-1,2-glucose, and in chloroeremomycin it is L-4-epi-vancosamine-1,2-glucose. The sugars and their substituents play an important role in efficacy, particularly against vancomycin-resistant pathogenic enterococci.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0969-2126
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
3
|
|
pubmed:volume |
9
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
547-57
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:11470430-Amino Acid Sequence,
pubmed-meshheading:11470430-Anti-Bacterial Agents,
pubmed-meshheading:11470430-Binding Sites,
pubmed-meshheading:11470430-Catalysis,
pubmed-meshheading:11470430-Crystallography, X-Ray,
pubmed-meshheading:11470430-Glucosyltransferases,
pubmed-meshheading:11470430-Glycosylation,
pubmed-meshheading:11470430-Models, Molecular,
pubmed-meshheading:11470430-Molecular Sequence Data,
pubmed-meshheading:11470430-Peptides,
pubmed-meshheading:11470430-Protein Conformation,
pubmed-meshheading:11470430-Sequence Homology, Amino Acid,
pubmed-meshheading:11470430-Vancomycin
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Structure of the UDP-glucosyltransferase GtfB that modifies the heptapeptide aglycone in the biosynthesis of vancomycin group antibiotics.
|
|
pubmed:affiliation |
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|
