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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-7-24
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pubmed:abstractText |
Pleomorphic carcinoma (PC) of the lung is an aggressive epithelial neoplasm composed of giant and/or spindle tumor cells and associated with short survival. Most patients are cigarette smokers. The tumor susceptibility gene P-450 1A1 (CYP1A1) is involved in the activation of polycyclic aromatic hydrocarbons, including benzo[a]pyrene, producing DNA-damaging epoxides that lead to G:C-->T:A point mutations. Isoleucine (Ile)-valine (Val) and Val-Val genotypes of the CYP1A1 exon 7 polymorphism are associated with an increased risk for lung cancer in certain populations.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1084-8592
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
109-15
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11468695-Alleles,
pubmed-meshheading:11468695-Benzo(a)pyrene,
pubmed-meshheading:11468695-Carcinogens,
pubmed-meshheading:11468695-Carcinoma,
pubmed-meshheading:11468695-Carcinoma, Giant Cell,
pubmed-meshheading:11468695-Cytochrome P-450 CYP1A1,
pubmed-meshheading:11468695-Exons,
pubmed-meshheading:11468695-Genotype,
pubmed-meshheading:11468695-Heterozygote,
pubmed-meshheading:11468695-Humans,
pubmed-meshheading:11468695-Lung Neoplasms,
pubmed-meshheading:11468695-Models, Chemical,
pubmed-meshheading:11468695-Mutation,
pubmed-meshheading:11468695-Phenotype,
pubmed-meshheading:11468695-Polymerase Chain Reaction,
pubmed-meshheading:11468695-Polymorphism, Genetic,
pubmed-meshheading:11468695-Proto-Oncogene Proteins,
pubmed-meshheading:11468695-Smoking,
pubmed-meshheading:11468695-ras Proteins
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pubmed:year |
2001
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pubmed:articleTitle |
Pleomorphic (giant and/or spindle cell) carcinoma of lung shows a high percentage of variant CYP1A12.
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pubmed:affiliation |
Department of Cellular Pathology and Genetics, The Armed Forces Institute of Pathology, 1413 Research Blvd., Bldg. 101, Rockville, MD 20850, USA. przygodz@afip.osd.mil
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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