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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0025914,
umls-concept:C0026609,
umls-concept:C0026809,
umls-concept:C0038838,
umls-concept:C0207072,
umls-concept:C0596988,
umls-concept:C1171362,
umls-concept:C1333669,
umls-concept:C1515670
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pubmed:issue |
2
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|
pubmed:dateCreated |
2001-7-24
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|
pubmed:abstractText |
An in vitro system of motoneurons was established from mice carrying a transgene for a human superoxide dismutase-1 (SOD-1) with a gly93ala mutation that has been linked to familial amyotrophic lateral sclerosis (FALS). These cultures were characterized and used to compare the effects of glial cell line-derived neurotrophic factor (GDNF) on motoneurons expressing the mutant gene with those on normal motoneurons.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1466-0822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
113-22
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11467048-Amyotrophic Lateral Sclerosis,
pubmed-meshheading:11467048-Animals,
pubmed-meshheading:11467048-Cell Survival,
pubmed-meshheading:11467048-Cells, Cultured,
pubmed-meshheading:11467048-Disease Models, Animal,
pubmed-meshheading:11467048-Female,
pubmed-meshheading:11467048-Glial Cell Line-Derived Neurotrophic Factor,
pubmed-meshheading:11467048-Male,
pubmed-meshheading:11467048-Mice,
pubmed-meshheading:11467048-Mice, Transgenic,
pubmed-meshheading:11467048-Motor Neurons,
pubmed-meshheading:11467048-Nerve Growth Factors,
pubmed-meshheading:11467048-Nerve Tissue Proteins,
pubmed-meshheading:11467048-Neuroprotective Agents,
pubmed-meshheading:11467048-Point Mutation,
pubmed-meshheading:11467048-Pregnancy,
pubmed-meshheading:11467048-Spinal Cord,
pubmed-meshheading:11467048-Superoxide Dismutase
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pubmed:year |
2000
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pubmed:articleTitle |
GDNF is trophic for mouse motoneurons that express a mutant superoxide dismutase (SOD-1) gene.
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pubmed:affiliation |
Program in Neuroscience, University of Rochester Medical Center, Northwestern University Medical School, Chicago, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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