Linked Life Data

11465811

Source:http://linkedlifedata.com/resource/pubmed/id/11465811

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2001-7-23
pubmed:abstractText
Recurrence of acute poststreptococcal glomerulonephritis (APSGN) is a rare phenomenon. We present an 8-year-old boy with a second episode of APSGN 12 months following a complete clinical recovery from his initial attack. Renal histology, obtained from renal biopsies of the patient during the second attack, showed diffuse endocapillary proliferation, granular deposition of C3, IgG, IgA, and fibrinogen along capillary walls, and subepithelial electron-dense deposits. A new streptococcal cytoplasmic antigen (nephritis-associated plasmin receptor protein, NAP1r), which was recently identified as the pathogenic antigen in APSGN, was detected in the glomeruli of an early kidney biopsy specimen from the patient during the second attack of APSGN, using fluorescein isothiocyanate-labeled rabbit anti-NAP1r. However, antibodies against NAP1r, examined by Western blotting, were not present in sera from the patient. These results suggest that recurrence of APSGN in some patients may be caused by an absence of a natural immune response to NAP1r.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0931-041X
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
598-600
pubmed:dateRevised
2004-11-23
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Recurrence of acute poststreptococcal glomerulonephritis.
pubmed:affiliation
Department of Pediatrics, Niigata City General Hospital, Niigata, Japan. twata@hosp.niigata.niigata.jp
pubmed:publicationType
Journal Article, Case Reports