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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2001-7-20
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pubmed:abstractText |
[reaction: see text] The 3-alkoxy-4-arylpiperidine inhibitors of aspartic peptidases are shown to be a new type of non-peptide peptidomimetic inhibitor. These piperidines can be designed from peptide-derived inhibitors by use of a structure-generating program but only after the enzyme active site conformation has been modified in a mechanistically related fashion. New enantioselective syntheses of 3-alkoxy-4-arylpiperidine analogues are described.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1523-7060
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2317-20
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11463305-Animals,
pubmed-meshheading:11463305-Aspartic Acid Endopeptidases,
pubmed-meshheading:11463305-Binding Sites,
pubmed-meshheading:11463305-Pepsin A,
pubmed-meshheading:11463305-Piperidines,
pubmed-meshheading:11463305-Protease Inhibitors,
pubmed-meshheading:11463305-Protein Structure, Secondary,
pubmed-meshheading:11463305-Renin,
pubmed-meshheading:11463305-Stereoisomerism,
pubmed-meshheading:11463305-Structure-Activity Relationship,
pubmed-meshheading:11463305-Swine
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pubmed:year |
2001
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pubmed:articleTitle |
From peptides to non-peptide peptidomimetics: design and synthesis of new piperidine inhibitors of aspartic peptidases.
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pubmed:affiliation |
Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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