Source:http://linkedlifedata.com/resource/pubmed/id/11461950
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2001-7-19
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| pubmed:abstractText |
Ganciclovir, which is used to treat cytomegalovirus (CMV) infection, has been shown in rodent models to abolish CMV-mediated chronic cellular damage and endothelial cell proliferation; when associated with mycophenolate mofetil (MMF), it has been shown to increase its anti-herpes virus activity. This study tested the hypothesis that kidney graft recipients who received antirejection prophylaxis with MMF and who were treated with ganciclovir for a declared CMV disease could be protected from chronic graft dysfunction. Investigated was the impact of ganciclovir-treated CMV diseases in consecutive first kidney recipients according to their immunosuppressive therapy. The azathioprine (Aza)-treated group (Aza group) included 319 patients. The MMF-treated group (MMF group) included 126 patients. CMV disease was clinically defined and confirmed by virological proof of CMV infection and was treated for at least 14 d with ganciclovir. Despite having the same incidence (21.6% in the Aza group versus 24.6% in the MMF group) and severity, CMV disease was significantly associated with graft loss independent of acute rejection episodes or other factors when tested in a Cox proportional model in the Aza group only (P < 10(-4)). It was shown for the first time that patients whose CMV disease is treated with ganciclovir while they are on MMF therapy are protected from the long-term deleterious consequences of CMV disease on graft survival, independent of acute rejection. It is suggested that the enhanced anti-herpes virus activity of ganciclovir by MMF could contribute to this reported effect, which may represent a significant contribution of MMF efficacy to graft survival.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Azathioprine,
http://linkedlifedata.com/resource/pubmed/chemical/Ganciclovir,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Mycophenolic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/mycophenolate mofetil
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
1046-6673
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1758-63
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11461950-Acute Disease,
pubmed-meshheading:11461950-Adolescent,
pubmed-meshheading:11461950-Adult,
pubmed-meshheading:11461950-Aged,
pubmed-meshheading:11461950-Antiviral Agents,
pubmed-meshheading:11461950-Azathioprine,
pubmed-meshheading:11461950-Chronic Disease,
pubmed-meshheading:11461950-Cytomegalovirus Infections,
pubmed-meshheading:11461950-Drug Therapy, Combination,
pubmed-meshheading:11461950-Female,
pubmed-meshheading:11461950-Ganciclovir,
pubmed-meshheading:11461950-Graft Rejection,
pubmed-meshheading:11461950-Graft Survival,
pubmed-meshheading:11461950-Humans,
pubmed-meshheading:11461950-Immunosuppressive Agents,
pubmed-meshheading:11461950-Incidence,
pubmed-meshheading:11461950-Kidney,
pubmed-meshheading:11461950-Kidney Transplantation,
pubmed-meshheading:11461950-Male,
pubmed-meshheading:11461950-Middle Aged,
pubmed-meshheading:11461950-Mycophenolic Acid,
pubmed-meshheading:11461950-Postoperative Complications
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| pubmed:year |
2001
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| pubmed:articleTitle |
Mycophenolate mofetil does not modify the incidence of cytomegalovirus (CMV) disease after kidney transplantation but prevents CMV-induced chronic graft dysfunction.
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| pubmed:affiliation |
Institut de Transplantation et de Recherche en Transplantation (ITERT) and INSERM U437, 30 Boulevard Jean Monnet, 44093 Nantes Cedex 1, France.
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| pubmed:publicationType |
Journal Article
|