Linked Life Data

11459940

Source:http://linkedlifedata.com/resource/pubmed/id/11459940

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
2001-8-1
pubmed:abstractText
Mice prefer to mate with individuals expressing different MHC genes from their own. Volatile components presenting MHC-dependent odor types are present in urine and can be detected by mice, as shown by extensive behavioral studies. Similar odor types are suspected to influence human behavior as well. Although a recent report indicates that MHC expression influences the ratio of volatile compounds such as phenylacetic acid, so far no other means than studying the behavior of mice or rats has been available to assess odor types. Here, we report the ability of a gas sensor array (referred to as "electronic nose") to detect MHC-dependent odor types. The electronic nose consists of an array of chemophysical detectors, in our case quartz crystal microbalances and semiconducting metal-oxide sensors that change frequency or conductivity upon binding of very small numbers of individual molecules present in the gas phase of odorous fluids. The pattern of changes is characteristic for a particular smell. Our electronic nose distinguishes the urine odor types of MHC congenic mouse strains, MHC class I mutant mice, and HLA-A2 transgenic mice. In addition, MHC-dependent odor types can be detected in serum. The device also clearly differentiates between individual odor types of human sera from HLA homozygous individuals; however, HLA expression seems to have only a secondary influence. Thus, odor-type research can now be carried out with an objective and fast through-put system independent of behavioral studies.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11459940-10912502, http://linkedlifedata.com/resource/pubmed/commentcorrection/11459940-1709722, http://linkedlifedata.com/resource/pubmed/commentcorrection/11459940-2236049, http://linkedlifedata.com/resource/pubmed/commentcorrection/11459940-2508616, http://linkedlifedata.com/resource/pubmed/commentcorrection/11459940-6946517, http://linkedlifedata.com/resource/pubmed/commentcorrection/11459940-7772286, http://linkedlifedata.com/resource/pubmed/commentcorrection/11459940-8170979, http://linkedlifedata.com/resource/pubmed/commentcorrection/11459940-8476560, http://linkedlifedata.com/resource/pubmed/commentcorrection/11459940-8476562, http://linkedlifedata.com/resource/pubmed/commentcorrection/11459940-9122173, http://linkedlifedata.com/resource/pubmed/commentcorrection/11459940-9326314, http://linkedlifedata.com/resource/pubmed/commentcorrection/11459940-9326315, http://linkedlifedata.com/resource/pubmed/commentcorrection/11459940-9646849, http://linkedlifedata.com/resource/pubmed/commentcorrection/11459940-9990056
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
31
pubmed:volume
98
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9249-54
pubmed:dateRevised
2010-9-14
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
"Electronic nose" detects major histocompatibility complex-dependent prerenal and postrenal odor components.
pubmed:affiliation
Department of Immunology, Institute for Cell Biology, Institute for Physical Chemistry, and Department of Transfusion Medicine, University of Tübingen, D-72076 Tübingen, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't