Source:http://linkedlifedata.com/resource/pubmed/id/11459791
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
2001-7-18
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pubmed:abstractText |
Cocaine- and amphetamine-regulated transcript is expressed in hypothalamic regions involved in the central control of food intake. Previous data have implicated cocaine- and amphetamine-regulated transcript as an anorectic peptide. We studied the effect of the active fragment of cocaine- and amphetamine-regulated transcript, cocaine- and amphetamine-regulated transcript-(55-102), on feeding when injected into discrete nuclei of the hypothalamus. Cocaine- and amphetamine-regulated transcript-(55-102) (0.04 nmol) elicited a delayed, but significant, increase in feeding in 24-h fasted rats after injection into the ventromedial nucleus (1-2 h, 261 +/- 60% of control; P < 0.05) and arcuate nucleus (1-2 h, 225 +/- 38% of control; P < 0.05) of the hypothalamus. Administration of a higher dose of cocaine- and amphetamine-regulated transcript-(55-102) (0.2 nmol) elicited a significant increase in feeding after injection into the ventromedial nucleus (1-2 h, 1253 +/- 179% of control; P < 0.001), arcuate nucleus (1-2 h, 265 +/- 43% of control; P < 0.05), paraventricular nucleus (2-4 h food intake, 186 +/- 29% of control; P < 0.05), lateral hypothalamic area (2-4 h, 280 +/- 34% of control; P < 0.001), anterior hypothalamic area (2-4 h, 252 +/- 42% of control; P < 0.01), dorsomedial nucleus (2-4 h, 368 +/- 29% of control;P < 0.001) and supraoptic nucleus (2-4 h, 212 +/- 34% of control; P < 0.05) of the hypothalamus. Administration of cocaine- and amphetamine-regulated transcript-(55-102) into the third ventricle of the hypothalamus resulted in an inhibition in feeding [0-4 h (0.4 nmol), 33 +/- 13% control; P < 0.001], but was associated with marked abnormalities in behavior, which may have interfered with feeding. These behavioral abnormalities were not observed after the administration of cocaine- and amphetamine-regulated transcript-(55-102) directly into the arcuate nucleus. These data suggest that cocaine- and amphetamine-regulated transcript may play an orexigenic role in the hypothalamic feeding circuitry.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/cocaine- and amphetamine-regulated...,
http://linkedlifedata.com/resource/pubmed/chemical/orexins
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0013-7227
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pubmed:author |
pubmed-author:AbbottC RCR,
pubmed-author:BloomS RSR,
pubmed-author:GhateiM AMA,
pubmed-author:KennedyA RAR,
pubmed-author:MorganD GDG,
pubmed-author:MorganII,
pubmed-author:MurphyK GKG,
pubmed-author:RossiMM,
pubmed-author:SmallC JCJ,
pubmed-author:StanleyS ASA,
pubmed-author:WrenA MAM,
pubmed-author:ZollnerA NAN
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pubmed:issnType |
Print
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pubmed:volume |
142
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3457-63
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11459791-Animals,
pubmed-meshheading:11459791-Behavior, Animal,
pubmed-meshheading:11459791-Carrier Proteins,
pubmed-meshheading:11459791-Eating,
pubmed-meshheading:11459791-Fasting,
pubmed-meshheading:11459791-Hypothalamus,
pubmed-meshheading:11459791-Injections,
pubmed-meshheading:11459791-Injections, Intraventricular,
pubmed-meshheading:11459791-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:11459791-Male,
pubmed-meshheading:11459791-Nerve Tissue Proteins,
pubmed-meshheading:11459791-Neuropeptides,
pubmed-meshheading:11459791-Peptide Fragments,
pubmed-meshheading:11459791-Rats,
pubmed-meshheading:11459791-Rats, Wistar,
pubmed-meshheading:11459791-Satiety Response
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pubmed:year |
2001
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pubmed:articleTitle |
Evidence of an orexigenic role for cocaine- and amphetamine-regulated transcript after administration into discrete hypothalamic nuclei.
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pubmed:affiliation |
Endocrine Unit, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom W12 ONN.
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pubmed:publicationType |
Journal Article
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