Source:http://linkedlifedata.com/resource/pubmed/id/11450865
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2001-7-13
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| pubmed:abstractText |
The aim of this study was to prospectively compare the clinical outcomes in HIV-2-infected and HIV-negative patients with culture-confirmed pulmonary tuberculosis, evaluate immunological changes and investigate risk factors for decreased survival in HIV-2-positive subjects. From 1994 to 1997, 127 consecutive patients with pulmonary tuberculosis were included at the Raoul Follereau Hospital in Bissau, the capital of Guinea-Bissau. All subjects were initially hospitalized, and then followed to the end of the 8-month treatment period. CD4 T-lymphocyte counts were determined by flow cytometry before, during and at the end of the treatment period. The prevalences of HIV-1, HIV-2 and HIV-1/HIV-2 dual reactivity were 8.7%, 23.6% and 9.4%, respectively (95% confidence intervals 3.8-13.6, 16.2-31.0 and 4.4-14.5, respectively). The mortality rate during the study period was significantly higher in HIV-2-positive (p < 0.01) and HIV-1/HIV-2 dually reactive (p < 0.01) patients than in HIV-negative individuals (52.9, 83.3 and 8.7 per 100 person-years, respectively). In HIV-1-positive patients the mortality rate was 30.8/100 person-years (p = NS). Baseline total CD4 cell counts were 213, 104, 235 and 624 x 10(6)/l (% CD4 = 17, 15, 20 and 40) among HIV-1-, HIV-2- and HIV-1/HIV-2-positive and HIV-negative subjects, respectively. The median rates of change per year of total CD4 cell counts in HIV-2-positive and HIV-negative subjects were 66 and 340 x 10(6)/l, respectively (interquartile ranges -78-249 and 21-624). In conclusion, we found a significantly higher mortality rate in HIV-2-positive compared to HIV-negative individuals. Baseline CD4 cell counts were markedly suppressed and similar in all 3 HIV-positive groups, and in a multivariate logistic regression analysis a value of CD4 percentage of < 10 was shown to be an independent predictor of decreased survival in HIV-2-infected subjects.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:issn |
0036-5548
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
33
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
450-6
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11450865-Adolescent,
pubmed-meshheading:11450865-Adult,
pubmed-meshheading:11450865-CD4 Lymphocyte Count,
pubmed-meshheading:11450865-Female,
pubmed-meshheading:11450865-Guinea-Bissau,
pubmed-meshheading:11450865-HIV Infections,
pubmed-meshheading:11450865-Hospitalization,
pubmed-meshheading:11450865-Humans,
pubmed-meshheading:11450865-Logistic Models,
pubmed-meshheading:11450865-Male,
pubmed-meshheading:11450865-Middle Aged,
pubmed-meshheading:11450865-Multivariate Analysis,
pubmed-meshheading:11450865-Prevalence,
pubmed-meshheading:11450865-Prospective Studies,
pubmed-meshheading:11450865-Risk Factors,
pubmed-meshheading:11450865-Severity of Illness Index,
pubmed-meshheading:11450865-Tuberculosis, Pulmonary
|
| pubmed:year |
2001
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| pubmed:articleTitle |
High mortality and severe immunosuppression in hospitalized patients with pulmonary tuberculosis and HIV-2 infection in Guinea-Bissau.
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| pubmed:affiliation |
National Public Health Laboratory, Bissau, Guinea-Bissau.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|