Linked Life Data

11441071

Source:http://linkedlifedata.com/resource/pubmed/id/11441071

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-7-6
pubmed:abstractText
Immunosurveillance of mucosal sites presents immune cells with challenges not encountered in the periphery. T cells in the gut must distinguish enteric pathogens from innocuous non-self Ag derived from food or commensal bacteria. The mechanisms that regulate T cells in the gut remain incompletely understood. We assessed the effect of the Peyer's patch microenvironment on T cell responses to chemokines. Chemokines are believed to play an important role during T cell priming by facilitating T cell migration into and within lymphoid tissues as well as T cell encounter and interaction with APCs. We found a profound suppression of chemokine-stimulated T cell chemotaxis and actin polymerization in Peyer's patch relative to lymph node. Chemokine hyporesponsiveness is imposed upon T cells within hours of their entry into Peyer's patches and is reversed following their removal. Suppression was not restricted to chemokine stimulation, as T cell responses to Con A and PMA were also suppressed. The global nature of this defect is further underscored by an impairment in calcium mobilization. Evidence indicates that a soluble factor contributes to this hyporesponsiveness, and comparison of Peyer's patches and lymph nodes revealed striking differences in their chemokine and cytokine constitution, indicating a marked Th2 bias in the Peyer's patches. The role of the Th2 microenvironment in mediating suppression is suggested by the ability of Nippostrongylus brasiliensis to elicit hyporesponsiveness in lymph node T cells. The suppressive milieu encountered by T cells in Peyer's patches may be critical for discouraging undesired immune responses and promoting tolerance.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
167
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
682-90
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:11441071-Actins, pubmed-meshheading:11441071-Adoptive Transfer, pubmed-meshheading:11441071-Animals, pubmed-meshheading:11441071-Chemokine CCL19, pubmed-meshheading:11441071-Chemokine CCL21, pubmed-meshheading:11441071-Chemokines, CC, pubmed-meshheading:11441071-Chemotaxis, Leukocyte, pubmed-meshheading:11441071-Cytokines, pubmed-meshheading:11441071-Female, pubmed-meshheading:11441071-Immune Tolerance, pubmed-meshheading:11441071-Lymph Nodes, pubmed-meshheading:11441071-Mice, pubmed-meshheading:11441071-Mice, Inbred BALB C, pubmed-meshheading:11441071-Mice, Inbred C3H, pubmed-meshheading:11441071-Mice, Inbred C57BL, pubmed-meshheading:11441071-Mice, Knockout, pubmed-meshheading:11441071-Mice, Transgenic, pubmed-meshheading:11441071-Peyer's Patches, pubmed-meshheading:11441071-Receptors, Chemokine, pubmed-meshheading:11441071-T-Lymphocyte Subsets, pubmed-meshheading:11441071-Time Factors
pubmed:year
2001
pubmed:articleTitle
The Peyer's patch microenvironment suppresses T cell responses to chemokines and other stimuli.
pubmed:affiliation
Department of Immunobiology, DNAX Research Institute, Palo Alto, CA 94304, USA. kellermann_s@abgenix.com
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't