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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2001-7-4
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pubmed:abstractText |
Periodic accumulation and destruction of mitotic cyclins are important for the initiation and termination of M phase. It is known that both APC(Cdc20) and APC(Hct1) collaborate to destroy mitotic cyclins during M phase. Here we show that this relationship between anaphase-promoting complex (APC) and Clb proteins is reversed in S phase such that the early Clb kinases (Clb3, Clb4, and Clb5 kinases) inactivate APC(Hct1) to allow Clb2 accumulation. This alternating antagonism between APC and Clb proteins during S and M phases constitutes an oscillatory system that generates undulations in the levels of mitotic cyclins.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438663-10074450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438663-10219244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438663-10235265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438663-10465783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438663-10548110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438663-10600711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438663-10647015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438663-10692575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438663-10793135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438663-10805723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438663-10882135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438663-10985373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438663-1387566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438663-1849457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438663-8020094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438663-8319908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438663-8402888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438663-8491189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438663-8601616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438663-8887667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438663-9288748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438663-9334304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438663-9469814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438663-9501986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438663-9831566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438663-9885559
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CDC20 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/CLB2 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin B,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclins,
http://linkedlifedata.com/resource/pubmed/chemical/Fungal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hct1 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Ligases,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin-Protein Ligase Complexes,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin-Protein Ligases,
http://linkedlifedata.com/resource/pubmed/chemical/anaphase-promoting complex
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5071-81
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11438663-Blotting, Northern,
pubmed-meshheading:11438663-Blotting, Western,
pubmed-meshheading:11438663-Cell Cycle Proteins,
pubmed-meshheading:11438663-Cyclin B,
pubmed-meshheading:11438663-Cyclins,
pubmed-meshheading:11438663-Flow Cytometry,
pubmed-meshheading:11438663-Fungal Proteins,
pubmed-meshheading:11438663-Gene Deletion,
pubmed-meshheading:11438663-Ligases,
pubmed-meshheading:11438663-Microscopy, Fluorescence,
pubmed-meshheading:11438663-Mitosis,
pubmed-meshheading:11438663-Models, Biological,
pubmed-meshheading:11438663-Mutation,
pubmed-meshheading:11438663-Phosphorylation,
pubmed-meshheading:11438663-Plasmids,
pubmed-meshheading:11438663-Protein Binding,
pubmed-meshheading:11438663-S Phase,
pubmed-meshheading:11438663-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:11438663-Time Factors,
pubmed-meshheading:11438663-Transcription, Genetic,
pubmed-meshheading:11438663-Ubiquitin-Protein Ligase Complexes,
pubmed-meshheading:11438663-Ubiquitin-Protein Ligases,
pubmed-meshheading:11438663-Yeasts
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pubmed:year |
2001
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pubmed:articleTitle |
Early expressed Clb proteins allow accumulation of mitotic cyclin by inactivating proteolytic machinery during S phase.
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pubmed:affiliation |
Institute of Molecular and Cell Biology, Singapore 117609, Singapore.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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