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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-7-3
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pubmed:abstractText |
Inflammation may contribute to lung injury and impaired alveolar development in bronchopulmonary dysplasia. We treated hyperoxia-exposed newborn rats with antibodies to the neutrophil chemokine cytokine-induced neutrophil chemoattractant-1 (CINC-1) during 95% O2 exposure to reduce adverse effects of hyperoxia-induced inflammation on lung development. Rats were exposed at birth to air, 95% O2, or 95% O2 + anti-CINC-1 (injected on days 3 and 4). Bromodeoxyuridine (BrdU) was injected 6 h before death. Anti-CINC-1 treatment improved weight gain but not survival at day 8. Anti-CINC-1 reduced bronchoalveolar lavage neutrophils at day 8 to levels equal to air controls. Total detectable lung CINC-1 was reduced to air control levels. Lung compliance was improved by anti-CINC-1, achieving air control levels in the 10-microg anti-CINC-1 group. Anti-CINC-1 preserved proliferating cell nuclear antigen expression in airway epithelium despite 95% O2 exposure. BrdU incorporation was depressed by hyperoxia but preserved by anti-CINC-1 to levels similar to air control. Alveolar volume and surface density were decreased by hyperoxia but preserved by anti-CINC-1 to levels equal to air control. Blockade of neutrophil influx in newborns may avert early lung injury and avoid alveolar developmental arrest that contributes to bronchopulmonary dysplasia.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Bromodeoxyuridine,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL1,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CXC,
http://linkedlifedata.com/resource/pubmed/chemical/Chemotactic Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Cxcl1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Proliferating Cell Nuclear Antigen
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1040-0605
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
281
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
L336-44
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11435208-Animals,
pubmed-meshheading:11435208-Animals, Newborn,
pubmed-meshheading:11435208-Antibodies,
pubmed-meshheading:11435208-Bromodeoxyuridine,
pubmed-meshheading:11435208-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:11435208-Cell Division,
pubmed-meshheading:11435208-Chemokine CXCL1,
pubmed-meshheading:11435208-Chemokines,
pubmed-meshheading:11435208-Chemokines, CXC,
pubmed-meshheading:11435208-Chemotactic Factors,
pubmed-meshheading:11435208-DNA,
pubmed-meshheading:11435208-Growth Substances,
pubmed-meshheading:11435208-Hyperoxia,
pubmed-meshheading:11435208-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:11435208-Leukocyte Count,
pubmed-meshheading:11435208-Lung,
pubmed-meshheading:11435208-Neutrophils,
pubmed-meshheading:11435208-Proliferating Cell Nuclear Antigen,
pubmed-meshheading:11435208-Pulmonary Alveoli,
pubmed-meshheading:11435208-Rats,
pubmed-meshheading:11435208-Survival Analysis,
pubmed-meshheading:11435208-Weight Gain
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pubmed:year |
2001
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pubmed:articleTitle |
Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats.
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pubmed:affiliation |
Division of Neonatal Medicine, Department of Pediatrics, Neonatal-Perinatal Research Institute, Durham, North Carolina 27710, USA. auten@duke.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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