|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0010823,
umls-concept:C0019772,
umls-concept:C0023884,
umls-concept:C0035015,
umls-concept:C0035648,
umls-concept:C0086860,
umls-concept:C0205191,
umls-concept:C0333516,
umls-concept:C1527362,
umls-concept:C1548437,
umls-concept:C1709854,
umls-concept:C1882923
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2001-7-3
|
|
pubmed:abstractText |
The tumour necrosis factor (TNF)-2 promoter allele, which elicits elevated expression of TNF-alpha, is in linkage disequilibrium with the extended haplotype HLA-A1-B8-DR3-DQ2. TNF-2 and HLA-DR3 have been implicated in renal and cardiac graft rejection and loss. Cytomegalovirus (CMV) infection has been associated with chronic allograft rejection. We examined the relationship between HLA-DR3, promoter allele TNF-2 and cytomegalovirus in relation to chronic rejection following liver transplantation.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0168-8278
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
34
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
711-5
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:11434617-Adolescent,
pubmed-meshheading:11434617-Adult,
pubmed-meshheading:11434617-Aged,
pubmed-meshheading:11434617-Alleles,
pubmed-meshheading:11434617-Chronic Disease,
pubmed-meshheading:11434617-Cytomegalovirus Infections,
pubmed-meshheading:11434617-Female,
pubmed-meshheading:11434617-Genetic Linkage,
pubmed-meshheading:11434617-Graft Rejection,
pubmed-meshheading:11434617-HLA-DR3 Antigen,
pubmed-meshheading:11434617-Humans,
pubmed-meshheading:11434617-Liver Transplantation,
pubmed-meshheading:11434617-Male,
pubmed-meshheading:11434617-Middle Aged,
pubmed-meshheading:11434617-Promoter Regions, Genetic,
pubmed-meshheading:11434617-Prospective Studies,
pubmed-meshheading:11434617-Retrospective Studies,
pubmed-meshheading:11434617-Risk Factors,
pubmed-meshheading:11434617-Tumor Necrosis Factor-alpha
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Recipient HLA-DR3, tumour necrosis factor-alpha promoter allele-2 (tumour necrosis factor-2) and cytomegalovirus infection are interrelated risk factors for chronic rejection of liver grafts.
|
|
pubmed:affiliation |
Department of Medicine, University School of Clinical Medicine, Addenbrooke's NHS Trust, Cambridge, UK.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
