| pubmed-article:11432746 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11432746 | lifeskim:mentions | umls-concept:C0070570 | lld:lifeskim |
| pubmed-article:11432746 | lifeskim:mentions | umls-concept:C1328815 | lld:lifeskim |
| pubmed-article:11432746 | lifeskim:mentions | umls-concept:C0066521 | lld:lifeskim |
| pubmed-article:11432746 | lifeskim:mentions | umls-concept:C0598460 | lld:lifeskim |
| pubmed-article:11432746 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:11432746 | pubmed:dateCreated | 2001-7-2 | lld:pubmed |
| pubmed-article:11432746 | pubmed:abstractText | Microperoxidase 8 (MP8) is a heme octapeptide obtained by hydrolytic digestion of horse heart cytochrome c. At pH below 9, the heme iron is axially coordinated to the imidazole side chain of His18 and to a water molecule. Replacement of this weak ligand by H2O2 allows the formation of high-valent iron-oxo species which are responsible for both peroxidase-like and cytochrome P450-like activities of MP8. This paper shows that MP8 is able to catalyze the nitration of phenol by nitrite. The reaction requires H2O2 and is inhibited by ligands having a high affinity for the iron, catalase and radical scavengers. This suggests that the nitrating species could be NO2* radicals formed by the oxidation of nitrite by high-valent iron-oxo species. This new activity of MP8 opens a new access to nitro-aromatic compounds under mild conditions and validates the use of this minienzyme to mimick heme peroxidases, especially in the reactions of NO-derived species with biomolecules under oxidative stress conditions. | lld:pubmed |
| pubmed-article:11432746 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11432746 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11432746 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11432746 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11432746 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11432746 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11432746 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11432746 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11432746 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11432746 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11432746 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11432746 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11432746 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11432746 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:11432746 | pubmed:issn | 0014-2956 | lld:pubmed |
| pubmed-article:11432746 | pubmed:author | pubmed-author:MansuyDD | lld:pubmed |
| pubmed-article:11432746 | pubmed:author | pubmed-author:BoucherJ LJL | lld:pubmed |
| pubmed-article:11432746 | pubmed:author | pubmed-author:MahyJ PJP | lld:pubmed |
| pubmed-article:11432746 | pubmed:author | pubmed-author:RicouxRR | lld:pubmed |
| pubmed-article:11432746 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11432746 | pubmed:volume | 268 | lld:pubmed |
| pubmed-article:11432746 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11432746 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11432746 | pubmed:pagination | 3783-8 | lld:pubmed |
| pubmed-article:11432746 | pubmed:dateRevised | 2007-7-23 | lld:pubmed |
| pubmed-article:11432746 | pubmed:meshHeading | pubmed-meshheading:11432746... | lld:pubmed |
| pubmed-article:11432746 | pubmed:meshHeading | pubmed-meshheading:11432746... | lld:pubmed |
| pubmed-article:11432746 | pubmed:meshHeading | pubmed-meshheading:11432746... | lld:pubmed |
| pubmed-article:11432746 | pubmed:meshHeading | pubmed-meshheading:11432746... | lld:pubmed |
| pubmed-article:11432746 | pubmed:meshHeading | pubmed-meshheading:11432746... | lld:pubmed |
| pubmed-article:11432746 | pubmed:meshHeading | pubmed-meshheading:11432746... | lld:pubmed |
| pubmed-article:11432746 | pubmed:meshHeading | pubmed-meshheading:11432746... | lld:pubmed |
| pubmed-article:11432746 | pubmed:meshHeading | pubmed-meshheading:11432746... | lld:pubmed |
| pubmed-article:11432746 | pubmed:meshHeading | pubmed-meshheading:11432746... | lld:pubmed |
| pubmed-article:11432746 | pubmed:meshHeading | pubmed-meshheading:11432746... | lld:pubmed |
| pubmed-article:11432746 | pubmed:meshHeading | pubmed-meshheading:11432746... | lld:pubmed |
| pubmed-article:11432746 | pubmed:meshHeading | pubmed-meshheading:11432746... | lld:pubmed |
| pubmed-article:11432746 | pubmed:meshHeading | pubmed-meshheading:11432746... | lld:pubmed |
| pubmed-article:11432746 | pubmed:meshHeading | pubmed-meshheading:11432746... | lld:pubmed |
| pubmed-article:11432746 | pubmed:meshHeading | pubmed-meshheading:11432746... | lld:pubmed |
| pubmed-article:11432746 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11432746 | pubmed:articleTitle | Microperoxidase 8 catalyzed nitration of phenol by nitrogen dioxide radicals. | lld:pubmed |
| pubmed-article:11432746 | pubmed:affiliation | Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, Université Paris V, France. | lld:pubmed |
| pubmed-article:11432746 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11432746 | lld:pubmed |
