Linked Life Data

11431729

Source:http://linkedlifedata.com/resource/pubmed/id/11431729

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-6-29
pubmed:abstractText
To assess whether an increased production of nitric oxide is involved in the circulatory and renal alterations of cirrhosis, we evaluated systemic hemodynamics (echocardiography), renal hemodynamics, and sodium handling (lithium clearance method), plasma renin activity (PRA), aldosterone (PAC), and norepinephrine in 7 patients (3 men, mean age 65 +/- 2 years) with compensated cirrhosis, portal hypertension, and hyperdynamic circulation during intravenous N(G)-monomethyl-L-arginine (L-NMMA) (3 mg/kg bolus plus 0.05 mg/kg. min for 120 minutes) or placebo (the vehicle) in a randomized, placebo-controlled, crossover study. Administration of L-NMMA resulted in significant reductions in plasma and urinary nitrite levels and plasma cyclic guanosine monophosphate (cGMP), indicating effective inhibition of nitric oxide synthase. L-NMMA also significantly reduced cardiac index (-13%) and increased systemic vascular resistance (+26%), arterial pressure (+9%), renal blood flow (+12%), glomerular filtration rate (+12%), and sodium excretion (+25%). Changes in sodium excretion were caused by both enhanced filtered sodium load and reduced sodium reabsorption in the proximal tubule. Plasma norepinephrine significantly decreased in response to L-NMMA, and there was a trend for reductions in PRA and PAC. Placebo had no appreciable effect on any of the measured parameters. These results indicate that in patients with compensated cirrhosis, portal hypertension and hyperdynamic circulation inhibition of nitric oxide synthase corrects the altered systemic hemodynamics and improves renal function and sodium excretion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0270-9139
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
19-27
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:11431729-Aged, pubmed-meshheading:11431729-Aldosterone, pubmed-meshheading:11431729-Blood Pressure, pubmed-meshheading:11431729-Cross-Over Studies, pubmed-meshheading:11431729-Enzyme Inhibitors, pubmed-meshheading:11431729-Female, pubmed-meshheading:11431729-Glomerular Filtration Rate, pubmed-meshheading:11431729-Hemodynamics, pubmed-meshheading:11431729-Humans, pubmed-meshheading:11431729-Hypertension, Portal, pubmed-meshheading:11431729-Kidney, pubmed-meshheading:11431729-Liver Cirrhosis, pubmed-meshheading:11431729-Male, pubmed-meshheading:11431729-Mesenteric Artery, Superior, pubmed-meshheading:11431729-Middle Aged, pubmed-meshheading:11431729-Nitric Oxide Synthase, pubmed-meshheading:11431729-Nitrites, pubmed-meshheading:11431729-Norepinephrine, pubmed-meshheading:11431729-Placebos, pubmed-meshheading:11431729-Renin, pubmed-meshheading:11431729-Sodium, pubmed-meshheading:11431729-Vascular Resistance, pubmed-meshheading:11431729-omega-N-Methylarginine
pubmed:year
2001
pubmed:articleTitle
Hemodynamic, renal, and endocrine effects of acute inhibition of nitric oxide synthase in compensated cirrhosis.
pubmed:affiliation
Department of Internal Medicine, University of Florence School of Medicine, Florence, Italy.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't