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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-6-29
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pubmed:abstractText |
Recent work has demonstrated that specific patterns of synaptic stimulation can induce long-term depression (LTD) in area CA1 that depends on activation of metabotropic glutamate receptors (mGluRs) and rapid protein synthesis. Here we show that the same form of synaptic modification can be induced by brief application of the selective mGluR agonist (RS)-3,5-dihydroxyphenylglycine (DHPG). DHPG-LTD 1) is a saturable form of synaptic plasticity, 2) requires mGluR5, 3) is mechanistically distinct from N-methyl-D-aspartate receptor (NMDAR)--dependent LTD, and 4) shares a common expression mechanism with protein synthesis-dependent LTD evoked using synaptic stimulation. DHPG-LTD should be useful for biochemical analysis of mGluR5- and protein synthesis-dependent synaptic modification.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-Amino-5-phosphonovalerate,
http://linkedlifedata.com/resource/pubmed/chemical/3,5-dihydroxyphenylglycine,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Glycine,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Metabotropic Glutamate,
http://linkedlifedata.com/resource/pubmed/chemical/Resorcinols,
http://linkedlifedata.com/resource/pubmed/chemical/metabotropic glutamate receptor 5
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-3077
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
321-5
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:11431513-2-Amino-5-phosphonovalerate,
pubmed-meshheading:11431513-Animals,
pubmed-meshheading:11431513-Excitatory Amino Acid Antagonists,
pubmed-meshheading:11431513-Excitatory Postsynaptic Potentials,
pubmed-meshheading:11431513-Glycine,
pubmed-meshheading:11431513-Hippocampus,
pubmed-meshheading:11431513-Long-Term Potentiation,
pubmed-meshheading:11431513-Mice,
pubmed-meshheading:11431513-Mice, Knockout,
pubmed-meshheading:11431513-Neural Inhibition,
pubmed-meshheading:11431513-Organ Culture Techniques,
pubmed-meshheading:11431513-RNA, Messenger,
pubmed-meshheading:11431513-Rats,
pubmed-meshheading:11431513-Rats, Long-Evans,
pubmed-meshheading:11431513-Receptors, Metabotropic Glutamate,
pubmed-meshheading:11431513-Resorcinols,
pubmed-meshheading:11431513-Stimulation, Chemical
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pubmed:year |
2001
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pubmed:articleTitle |
Chemical induction of mGluR5- and protein synthesis--dependent long-term depression in hippocampal area CA1.
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pubmed:affiliation |
Department of Neuroscience, Howard Hughes Medical Institute, Brown University, Providence, Rhode Island 02912, USA.
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pubmed:publicationType |
Journal Article
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