Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
27
pubmed:dateCreated
2001-6-28
pubmed:abstractText
The complex insulin-like growth factor network of ligands, receptors and binding proteins has been shown to be disturbed in breast cancer. In addition to defects in proteins controlling cell cycle checkpoints, this type of aberrations could affect tumor growth and survival thereby influencing both tumor aggressiveness and potential response to treatments. We have previously identified the T1A12/mac25 protein, which is identical to the IGFBP-rP1, as a differentially expressed gene product in breast cancer cells compared with normal cells. Here we compare the expression of IGFBP-rP1 in 106 tumor samples with known status of cell cycle aberrations and other clinicopathological data. This was done using a tumor tissue section array system that allows for simultaneous immunohistochemical staining of all samples in parallel. Cytoplasmic staining of variable intensity was observed in most tumors, 15% lacked IGFBP-rP1 staining completely, 20% had weak staining, 32% intermediate and 33% showed strong staining. Low IGFBP-rP1 was associated with high cyclin E protein content, retinoblastoma protein (pRb) inactivation, low bcl-2 protein, poorly differentiated tumors and higher stage. There was a significantly impaired prognosis for patients with low IGFBP-rP1 protein tumors. Interestingly, IGFBP-rP1 showed an inverse association with proliferation (Ki-67%) in estrogen receptor negative tumors as well as in cyclin E high tumors suggesting a separate cell cycle regulatory function for IGFBP-rP1 independent of interaction with the estrogen receptor or the pRb pathway.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Cyclin D1, http://linkedlifedata.com/resource/pubmed/chemical/Cyclin E, http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor Binding..., http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Progesterone, http://linkedlifedata.com/resource/pubmed/chemical/Retinoblastoma Protein, http://linkedlifedata.com/resource/pubmed/chemical/Telomerase, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53, http://linkedlifedata.com/resource/pubmed/chemical/insulin-like growth factor binding...
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0950-9232
pubmed:author
pubmed:issnType
Print
pubmed:day
14
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3497-505
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11429696-Aneuploidy, pubmed-meshheading:11429696-Breast Neoplasms, pubmed-meshheading:11429696-Carrier Proteins, pubmed-meshheading:11429696-Cell Cycle, pubmed-meshheading:11429696-Cyclin D1, pubmed-meshheading:11429696-Cyclin E, pubmed-meshheading:11429696-Diploidy, pubmed-meshheading:11429696-Female, pubmed-meshheading:11429696-Gene Expression Regulation, Neoplastic, pubmed-meshheading:11429696-Genes, Tumor Suppressor, pubmed-meshheading:11429696-Genes, bcl-2, pubmed-meshheading:11429696-Genes, erbB-2, pubmed-meshheading:11429696-Genes, p53, pubmed-meshheading:11429696-Humans, pubmed-meshheading:11429696-Immunohistochemistry, pubmed-meshheading:11429696-Insulin-Like Growth Factor Binding Proteins, pubmed-meshheading:11429696-Lymphatic Metastasis, pubmed-meshheading:11429696-Menopause, pubmed-meshheading:11429696-Neoplasm Invasiveness, pubmed-meshheading:11429696-Neoplasm Staging, pubmed-meshheading:11429696-Polymorphism, Single-Stranded Conformational, pubmed-meshheading:11429696-Prognosis, pubmed-meshheading:11429696-Receptors, Estrogen, pubmed-meshheading:11429696-Receptors, Progesterone, pubmed-meshheading:11429696-Retinoblastoma Protein, pubmed-meshheading:11429696-Telomerase, pubmed-meshheading:11429696-Tumor Markers, Biological, pubmed-meshheading:11429696-Tumor Suppressor Protein p53
pubmed:year
2001
pubmed:articleTitle
Downregulation of the potential suppressor gene IGFBP-rP1 in human breast cancer is associated with inactivation of the retinoblastoma protein, cyclin E overexpression and increased proliferation in estrogen receptor negative tumors.
pubmed:affiliation
Division of Pathology, Department of Laboratory Medicine, Lund University, Malmö University Hospital, Malmö, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't