Linked Life Data

11427999

Source:http://linkedlifedata.com/resource/pubmed/id/11427999

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2001-6-28
pubmed:abstractText
As the genetic nature of a wide spectrum of cardiovascular diseases is being elucidated, it is increasingly important to understand the functional role of specific genes on cardiac arrhythmia and conduction disturbances. The progress made in molecular genetics has allowed the creation of mice with targeted gene overexpression or elimination. These animals are valuable tools for researchers who have adapted their clinical and technical skills to the mouse, in order to extract information on the phenotypic consequences of the specific genetic disruption. In this review, we summarize the progress made in the field of invasive murine electrophysiology, focusing on the recent technical advances in in vivo electrophysiologic testing and its application to various genetically engineered mouse models. The authors' views on the future needs and trends in the field are also presented.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1050-1738
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
122-32
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Invasive cardiac electrophysiology in the mouse: techniques and applications.
pubmed:affiliation
New England Cardiac Arrhythmia Center, Tufts University-New England Medical Center, Boston, Massachusetts, USA. mestes@lifespan.org
pubmed:publicationType
Journal Article, Review