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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-6-25
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pubmed:abstractText |
Our previous studies have demonstrated that renal proximal tubular epithelial cells (PTCs) may contribute to renal interstitial fibrosis by the generation of transforming growth factor-beta1 (TGF-beta1). In these in vitro experiments, TGF-beta1 was, however, secreted in its latent form. Plasmin has been implicated as a potential physiological activator of TGF-beta1. The inter-alpha-trypsin inhibitor (IalphaI) family of serum protease inhibitors together with tumor necrosis factor-stimulated gene 6 (TSG-6) recently have been implicated in the regulation of this protease pathway. The aim of the current study was to examine PTC synthesis of these proteins and to relate it to alterations of plasmin-protease activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alpha-Globulins,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Cycloheximide,
http://linkedlifedata.com/resource/pubmed/chemical/Fibrinolysin,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Synthesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/SPINT2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TNFAIP6 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Trypsin Inhibitor, Kunitz Soybean,
http://linkedlifedata.com/resource/pubmed/chemical/inter-alpha-inhibitor
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
126-36
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11422744-Alpha-Globulins,
pubmed-meshheading:11422744-Cell Adhesion Molecules,
pubmed-meshheading:11422744-Cell Line,
pubmed-meshheading:11422744-Cycloheximide,
pubmed-meshheading:11422744-Epithelial Cells,
pubmed-meshheading:11422744-Fibrinolysin,
pubmed-meshheading:11422744-Glucose,
pubmed-meshheading:11422744-Humans,
pubmed-meshheading:11422744-Interleukin-1,
pubmed-meshheading:11422744-Kidney Tubules, Proximal,
pubmed-meshheading:11422744-Membrane Glycoproteins,
pubmed-meshheading:11422744-Peptide Fragments,
pubmed-meshheading:11422744-Protein Synthesis Inhibitors,
pubmed-meshheading:11422744-RNA, Messenger,
pubmed-meshheading:11422744-Trypsin Inhibitor, Kunitz Soybean
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pubmed:year |
2001
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pubmed:articleTitle |
Expression of inter-alpha-trypsin inhibitor and tumor necrosis factor-stimulated gene 6 in renal proximal tubular epithelial cells.
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pubmed:affiliation |
Institute of Nephrology, University of Wales College of Medicine, Cardiff, Wales, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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