Linked Life Data

11413743

Source:http://linkedlifedata.com/resource/pubmed/id/11413743

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2001-6-20
pubmed:abstractText
The safety of a haemostatic and wound dressing collagen pad (Antema) obtained from horse Achilles tendon treated with pepsin, has been studied from the immunological point of view. A sensitizing activity test and maximization test in guinea pig has been performed and its capacity of inducing antibodies has been tested in rabbit and man. In guinea pig the collagen pad tested did not show any symptom of allergic reaction, in rabbit it induced a weak immunological response, without any clinical symptoms, detectable with the ELISA method only at very high serum concentration levels (1:20). In a clinical trial, 20 patients submitted to different types of surgery in which the product had been used as haemostatic pad and left in the surgery area until absorption, did not develop any immunological clinical reaction. One year after the operation no traces of anti-collagen antibodies have been found with the ELISA method in the sera of those patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
414-9
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Immunological safety evaluation of a horse collagen haemostatic pad.
pubmed:affiliation
Opocrin S.p.A., Corlo di Formigine, Modena, Italy.
pubmed:publicationType
Journal Article