Linked Life Data

11413318

Source:http://linkedlifedata.com/resource/pubmed/id/11413318

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
2001-6-19
pubmed:abstractText
We measured the longitudinal responses to 95 HLA class I-restricted human immunodeficiency virus (HIV) epitopes and an immunodominant HLA A2-restricted cytomegalovirus (CMV) epitope in eight treatment-naive HIV-infected individuals, using intracellular cytokine staining. Patients were treated with highly active antiretroviral therapy (HAART) for a median of 78 weeks (range, 34 to 121 weeks). Seven of eight patients maintained an undetectable viral load for the duration of therapy. A rapid decline in HIV-specific CD8(+) T-cell response was observed at initiation of therapy. After an undetectable viral load was achieved, a slower decrease in HIV-specific CD8(+) T-cell response was observed that was well described by first-order kinetics. The median half-life for the rate of decay was 38.8 (20.3 to 68.0) weeks when data were expressed as percentage of peripheral CD8(+) T cells. In most cases, data were similar when expressed as the number of responding CD8(+) T cells per microliter of blood. In subjects who responded to more than one HIV epitope, rates of decline in response to the different epitopes were similar and varied by a factor of 2.2 or less. Discontinuation of treatment resulted in a rapid increase in HIV-specific CD8(+) T cells. Responses to CMV increased 1.6- and 2.8-fold within 16 weeks of initiation of HAART in two of three patients with a measurable CMV response. These data suggest that HAART quickly starts to restore CD8(+) T-cell responses to other chronic viral infections and leads to a slow decrease in HIV-specific CD8(+) T-cell response in HIV-infected patients. The slow decrease in the rate of CD8(+) T-cell response and rapid increase in response to recurrent viral replication suggest that the decrease in CD8(+) T-cell response observed represents a normal memory response to withdrawal of antigen.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11413318-10229228, http://linkedlifedata.com/resource/pubmed/commentcorrection/11413318-10400770, http://linkedlifedata.com/resource/pubmed/commentcorrection/11413318-10438796, http://linkedlifedata.com/resource/pubmed/commentcorrection/11413318-10482568, http://linkedlifedata.com/resource/pubmed/commentcorrection/11413318-10491418, http://linkedlifedata.com/resource/pubmed/commentcorrection/11413318-10756025, http://linkedlifedata.com/resource/pubmed/commentcorrection/11413318-10903781, http://linkedlifedata.com/resource/pubmed/commentcorrection/11413318-10982361, http://linkedlifedata.com/resource/pubmed/commentcorrection/11413318-11029005, http://linkedlifedata.com/resource/pubmed/commentcorrection/11413318-11120778, http://linkedlifedata.com/resource/pubmed/commentcorrection/11413318-9488268, http://linkedlifedata.com/resource/pubmed/commentcorrection/11413318-9491999, http://linkedlifedata.com/resource/pubmed/commentcorrection/11413318-9701254, http://linkedlifedata.com/resource/pubmed/commentcorrection/11413318-9847391, http://linkedlifedata.com/resource/pubmed/commentcorrection/11413318-9952380, http://linkedlifedata.com/resource/pubmed/commentcorrection/11413318-9973442
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6508-16
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Decay kinetics of human immunodeficiency virus-specific CD8+ T cells in peripheral blood after initiation of highly active antiretroviral therapy.
pubmed:affiliation
Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX 75390-9113, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't