The application of the bioisosteric concept between a furanose ring and a cyclohexene ring in the nucleoside field has led to the discovery of new potent antiviral agents.
Laboratory of Medicinal Chemistry, K.U. Leuven, Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven, Belgium. piet.herdewijn@rega.kuleuven.ac.be