Linked Life Data

1139829

Source:http://linkedlifedata.com/resource/pubmed/id/1139829

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
108
pubmed:dateCreated
1975-9-18
pubmed:abstractText
Undecalcified bone biopsy specimens from 10 normal individuals and 8 osteogenesis imperfecta patients, 2 to 30 years of age, were analyzed using microradiography as well as ultraviolet, tungsten and polarized light microscope techniques. Biopsies of ribs most reliably reflected the disease process of osteogenesis imperfecta when compared to those biopsies of long bones in the lower extremities deformed enough to require corrective surgery. The rib biopsies consistently revealed that there is a rapid surface turnover of histologically well-organized but osteopenic bone. The high rate of bone turnover is similar to that seen in very young normals but in osteogenesis imperfecta turnover rate does not appear to decline with age. The percentage of surface involved in active new bone formation and in osteoclastic resorption is notably elevated. Excessive osteocyte osteolysis is also characteristic.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0009-921X
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
204-13
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Osteogenesis imperfecta tarda. The morphology of rib biopsies.
pubmed:publicationType
Journal Article, Comparative Study