| pubmed-article:11397944 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11397944 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11397944 | lifeskim:mentions | umls-concept:C0242632 | lld:lifeskim |
| pubmed-article:11397944 | lifeskim:mentions | umls-concept:C0036576 | lld:lifeskim |
| pubmed-article:11397944 | lifeskim:mentions | umls-concept:C1420610 | lld:lifeskim |
| pubmed-article:11397944 | pubmed:issue | 5523 | lld:pubmed |
| pubmed-article:11397944 | pubmed:dateCreated | 2001-6-8 | lld:pubmed |
| pubmed-article:11397944 | pubmed:abstractText | How cytokines control differentiation of helper T (TH) cells is controversial. We show that T-bet, without apparent assistance from interleukin 12 (IL-12)/STAT4, specifies TH1 effector fate by targeting chromatin remodeling to individual interferon-gamma (IFN-gamma) alleles and by inducing IL-12 receptor beta2 expression. Subsequently, it appears that IL-12/STAT4 serves two essential functions in the development of TH1 cells: as growth signal, inducing survival and cell division; and as trans-activator, prolonging IFN-gamma synthesis through a genetic interaction with the coactivator, CREB-binding protein. These results suggest that a cytokine does not simply induce TH fate choice but instead may act as an essential secondary stimulus that mediates selective survival of a lineage. | lld:pubmed |
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| pubmed-article:11397944 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11397944 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11397944 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11397944 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11397944 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:11397944 | pubmed:author | pubmed-author:LeeH WHW | lld:pubmed |
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| pubmed-article:11397944 | pubmed:author | pubmed-author:YangS YSY | lld:pubmed |
| pubmed-article:11397944 | pubmed:author | pubmed-author:SimL HLH | lld:pubmed |
| pubmed-article:11397944 | pubmed:author | pubmed-author:ReinerS LSL | lld:pubmed |
| pubmed-article:11397944 | pubmed:author | pubmed-author:CerebNN | lld:pubmed |
| pubmed-article:11397944 | pubmed:author | pubmed-author:KENTNN | lld:pubmed |
| pubmed-article:11397944 | pubmed:author | pubmed-author:HutchinsA SAS | lld:pubmed |
| pubmed-article:11397944 | pubmed:author | pubmed-author:KentB CBC | lld:pubmed |
| pubmed-article:11397944 | pubmed:author | pubmed-author:MullenA CAC | lld:pubmed |
| pubmed-article:11397944 | pubmed:author | pubmed-author:VillarinoA... | lld:pubmed |
| pubmed-article:11397944 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11397944 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:11397944 | pubmed:volume | 292 | lld:pubmed |
| pubmed-article:11397944 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11397944 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11397944 | pubmed:pagination | 1907-10 | lld:pubmed |
| pubmed-article:11397944 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:11397944 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11397944 | pubmed:articleTitle | Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. | lld:pubmed |
| pubmed-article:11397944 | pubmed:affiliation | Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA. | lld:pubmed |
| pubmed-article:11397944 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11397944 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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