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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5523
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pubmed:dateCreated |
2001-6-8
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pubmed:abstractText |
How cytokines control differentiation of helper T (TH) cells is controversial. We show that T-bet, without apparent assistance from interleukin 12 (IL-12)/STAT4, specifies TH1 effector fate by targeting chromatin remodeling to individual interferon-gamma (IFN-gamma) alleles and by inducing IL-12 receptor beta2 expression. Subsequently, it appears that IL-12/STAT4 serves two essential functions in the development of TH1 cells: as growth signal, inducing survival and cell division; and as trans-activator, prolonging IFN-gamma synthesis through a genetic interaction with the coactivator, CREB-binding protein. These results suggest that a cytokine does not simply induce TH fate choice but instead may act as an essential secondary stimulus that mediates selective survival of a lineage.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CREB-Binding Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Crebbp protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Histones,
http://linkedlifedata.com/resource/pubmed/chemical/Il12rb2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/STAT4 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/T-Box Domain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/T-box transcription factor TBX21,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0036-8075
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pubmed:author |
pubmed-author:CerebNN,
pubmed-author:HutchinsA SAS,
pubmed-author:KENTNN,
pubmed-author:KentB CBC,
pubmed-author:LeeH WHW,
pubmed-author:LivingstonD MDM,
pubmed-author:MullenA CAC,
pubmed-author:ReinerS LSL,
pubmed-author:SimL HLH,
pubmed-author:VillarinoA VAV,
pubmed-author:YangS YSY
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
292
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1907-10
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11397944-Alleles,
pubmed-meshheading:11397944-Animals,
pubmed-meshheading:11397944-CREB-Binding Protein,
pubmed-meshheading:11397944-Cell Differentiation,
pubmed-meshheading:11397944-Cell Division,
pubmed-meshheading:11397944-Cell Lineage,
pubmed-meshheading:11397944-Cells, Cultured,
pubmed-meshheading:11397944-DNA-Binding Proteins,
pubmed-meshheading:11397944-Gene Expression Regulation,
pubmed-meshheading:11397944-Histones,
pubmed-meshheading:11397944-Interferon-gamma,
pubmed-meshheading:11397944-Interleukin-12,
pubmed-meshheading:11397944-Lymphocyte Activation,
pubmed-meshheading:11397944-Mice,
pubmed-meshheading:11397944-Mice, Inbred BALB C,
pubmed-meshheading:11397944-Mice, Inbred C57BL,
pubmed-meshheading:11397944-Nuclear Proteins,
pubmed-meshheading:11397944-RNA, Messenger,
pubmed-meshheading:11397944-Receptors, Interleukin,
pubmed-meshheading:11397944-Receptors, Interleukin-12,
pubmed-meshheading:11397944-STAT4 Transcription Factor,
pubmed-meshheading:11397944-Signal Transduction,
pubmed-meshheading:11397944-T-Box Domain Proteins,
pubmed-meshheading:11397944-Th1 Cells,
pubmed-meshheading:11397944-Trans-Activators,
pubmed-meshheading:11397944-Transcription Factors
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pubmed:year |
2001
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pubmed:articleTitle |
Role of T-bet in commitment of TH1 cells before IL-12-dependent selection.
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pubmed:affiliation |
Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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