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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
32
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pubmed:dateCreated |
2001-8-6
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pubmed:abstractText |
Hgs/Hrs is a tyrosine-phosphorylated FYVE finger protein that is induced by stimulation with various cytokines and growth factors. Here we show that Hgs plays critical roles in the signaling pathway for the interleukin-2-induced activation of the serum-response element and cyclic AMP-response element of the c-fos promoter. We found that Hgs associated physically with transforming growth factor-beta-activated kinase 1 (TAK1) and p21-activated kinase 1 (Pak1), which mediate the activation of c-Jun N-terminal kinase and serum response factor, respectively, leading to transactivation via the serum-response element and cyclic AMP-response element. These results suggest that Hgs is involved in the TAK1-JNK and Pak1-serum response factor pathways for the c-fos induction that is initiated by cytokines.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte-Macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Luciferases,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/MAP kinase kinase kinase 7,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PAK1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Pak1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-fos,
http://linkedlifedata.com/resource/pubmed/chemical/Serum Response Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/p21-Activated Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
276
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
29943-52
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:11397816-Animals,
pubmed-meshheading:11397816-Base Sequence,
pubmed-meshheading:11397816-Cell Line,
pubmed-meshheading:11397816-Cytokines,
pubmed-meshheading:11397816-DNA-Binding Proteins,
pubmed-meshheading:11397816-Enzyme Activation,
pubmed-meshheading:11397816-Genes, Dominant,
pubmed-meshheading:11397816-Genes, Reporter,
pubmed-meshheading:11397816-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:11397816-Humans,
pubmed-meshheading:11397816-Immunoblotting,
pubmed-meshheading:11397816-Interleukin-2,
pubmed-meshheading:11397816-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:11397816-Luciferases,
pubmed-meshheading:11397816-MAP Kinase Kinase Kinases,
pubmed-meshheading:11397816-Mice,
pubmed-meshheading:11397816-Mitogen-Activated Protein Kinases,
pubmed-meshheading:11397816-Molecular Sequence Data,
pubmed-meshheading:11397816-Nuclear Proteins,
pubmed-meshheading:11397816-Phosphorylation,
pubmed-meshheading:11397816-Plasmids,
pubmed-meshheading:11397816-Precipitin Tests,
pubmed-meshheading:11397816-Promoter Regions, Genetic,
pubmed-meshheading:11397816-Protein Binding,
pubmed-meshheading:11397816-Protein-Serine-Threonine Kinases,
pubmed-meshheading:11397816-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:11397816-Serum Response Factor,
pubmed-meshheading:11397816-Signal Transduction,
pubmed-meshheading:11397816-Time Factors,
pubmed-meshheading:11397816-Transcriptional Activation,
pubmed-meshheading:11397816-Tyrosine,
pubmed-meshheading:11397816-p21-Activated Kinases
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pubmed:year |
2001
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pubmed:articleTitle |
Involvement of Hgs/Hrs in signaling for cytokine-mediated c-fos induction through interaction with TAK1 and Pak1.
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pubmed:affiliation |
Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine and CREST Program of the Japan Science, and Technology Corporation, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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