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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2001-6-5
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pubmed:abstractText |
Highly selective arabinofuranosyl nucleosides, which inhibit the mitochondrial thymidine kinase (TK-2) without affecting the closely related herpes simplex virus type 1 thymidine kinase (HSV-1 TK), varicella-zoster virus thymidine kinase (VZV-TK), cytosolic thymidine kinase (TK-1) or the multifunctional Drosophila melanogaster deoxyribonucleoside kinase (Dm-dNK), have been obtained. SAR studies indicate a close relation between the length of the substituent at the 2' position of the arabinofuranosyl moiety and the inhibitory activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1329-32
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11392548-Arabinonucleosides,
pubmed-meshheading:11392548-Catalytic Domain,
pubmed-meshheading:11392548-Drug Design,
pubmed-meshheading:11392548-Enzyme Inhibitors,
pubmed-meshheading:11392548-Humans,
pubmed-meshheading:11392548-Inhibitory Concentration 50,
pubmed-meshheading:11392548-Mitochondria,
pubmed-meshheading:11392548-Models, Molecular,
pubmed-meshheading:11392548-Structure-Activity Relationship,
pubmed-meshheading:11392548-Thymidine Kinase,
pubmed-meshheading:11392548-Viral Proteins
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pubmed:year |
2001
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pubmed:articleTitle |
Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors.
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pubmed:affiliation |
Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Italy. mv9@dns.unfie.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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