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pubmed-article:11391236pubmed:abstractTextThe multifunctional cytokine transforming growth factor- (TGF) beta1 is thought to play a role in the pathogenesis of graft vascular disease (GVD). Polymorphisms at codon 10, (Leu10-->Pro) and codon 25 (Arg25-->Pro) in the signal sequence of the TGF-beta1 gene regulate the production and secretion of the protein. We investigated whether these polymorphisms are risk factors for the development of GVD after clinical heart transplantation.lld:pubmed
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pubmed-article:11391236pubmed:articleTitleThe transforming growth factor-beta1 codon 10 gene polymorphism and accelerated graft vascular disease after clinical heart transplantation.lld:pubmed
pubmed-article:11391236pubmed:affiliationUniversity Hospital Rotterdam-Dijkzigt, Department of Internal Medicine, Room Bd293, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.lld:pubmed
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