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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2001-6-6
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pubmed:abstractText |
The multifunctional cytokine transforming growth factor- (TGF) beta1 is thought to play a role in the pathogenesis of graft vascular disease (GVD). Polymorphisms at codon 10, (Leu10-->Pro) and codon 25 (Arg25-->Pro) in the signal sequence of the TGF-beta1 gene regulate the production and secretion of the protein. We investigated whether these polymorphisms are risk factors for the development of GVD after clinical heart transplantation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0041-1337
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1463-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11391236-Adult,
pubmed-meshheading:11391236-Aged,
pubmed-meshheading:11391236-Aging,
pubmed-meshheading:11391236-Codon,
pubmed-meshheading:11391236-Coronary Disease,
pubmed-meshheading:11391236-Genetic Predisposition to Disease,
pubmed-meshheading:11391236-Graft vs Host Disease,
pubmed-meshheading:11391236-Heart Transplantation,
pubmed-meshheading:11391236-Humans,
pubmed-meshheading:11391236-Middle Aged,
pubmed-meshheading:11391236-Polymorphism, Genetic,
pubmed-meshheading:11391236-Time Factors,
pubmed-meshheading:11391236-Tissue Donors,
pubmed-meshheading:11391236-Transforming Growth Factor beta,
pubmed-meshheading:11391236-Transforming Growth Factor beta1
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pubmed:year |
2001
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pubmed:articleTitle |
The transforming growth factor-beta1 codon 10 gene polymorphism and accelerated graft vascular disease after clinical heart transplantation.
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pubmed:affiliation |
University Hospital Rotterdam-Dijkzigt, Department of Internal Medicine, Room Bd293, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
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pubmed:publicationType |
Journal Article
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