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rdf:type |
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lifeskim:mentions |
umls-concept:C0002131,
umls-concept:C0007634,
umls-concept:C0205263,
umls-concept:C0220905,
umls-concept:C0332206,
umls-concept:C0439662,
umls-concept:C1332714,
umls-concept:C1334114,
umls-concept:C1514873,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C1704410
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pubmed:issue |
11
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pubmed:dateCreated |
2001-6-6
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pubmed:abstractText |
Immune regulatory CD4(+)CD25(+) cells play a vital role in the induction and maintenance of self-tolerance and are essential for T cell homeostasis and the prevention of autoimmunity. Induction of tolerance to allogeneic donor grafts is a clinically desirable goal in bone marrow and solid organ transplantation. To determine whether CD4(+)CD25(+) cells regulate T cell responses to alloantigen and are critical for tolerance induction, murine CD4(+) T cells were tolerized to alloantigen via ex vivo CD40 ligand (CD40L)/CD40 or CD28/cytotoxic T lymphocyte-associated antigen 4/B7 blockade resulting in secondary mixed leukocyte reaction hyporesponsiveness and tolerance to alloantigen in vivo. CD4(+)CD25(+) T cells were found to be potent regulators of alloresponses. Depletion of CD4(+)CD25(+) T cells from the CD4(+) responder population completely abrogated ex vivo tolerance induction to alloantigen as measured by intact responses to alloantigen restimulation in vitro and in vivo. Addback of CD4(+)CD25(+) T cells to CD4(+)CD25(-) cultures restored tolerance induction. These data are the first to indicate that CD4(+)CD25(+) cells are essential for the induction of tolerance to alloantigen and have important implications for tolerance-inducing strategies targeted at T cell costimulatory pathways.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-10371508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-10490963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-10553041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-10605010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-10623802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-10706892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-10742157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-10837065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-10861026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-10898488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-10899916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-10899917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-2113314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-7533092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-7568172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-7584142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-7636184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-7759894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-8759770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-8760792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-8977172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-9133420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-9233610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-9238056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-9570536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-9670041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-9691083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11390438-9885918
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CD40 Ligand,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Ctla4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates,
http://linkedlifedata.com/resource/pubmed/chemical/Isoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/abatacept
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
193
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1311-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11390438-Animals,
pubmed-meshheading:11390438-Antibodies, Monoclonal,
pubmed-meshheading:11390438-Antigens, CD,
pubmed-meshheading:11390438-Antigens, CD28,
pubmed-meshheading:11390438-Antigens, CD4,
pubmed-meshheading:11390438-Antigens, CD80,
pubmed-meshheading:11390438-Antigens, Differentiation,
pubmed-meshheading:11390438-CD40 Ligand,
pubmed-meshheading:11390438-CTLA-4 Antigen,
pubmed-meshheading:11390438-Graft vs Host Disease,
pubmed-meshheading:11390438-Immune Tolerance,
pubmed-meshheading:11390438-Immunoconjugates,
pubmed-meshheading:11390438-Isoantigens,
pubmed-meshheading:11390438-Lymphocyte Activation,
pubmed-meshheading:11390438-Mice,
pubmed-meshheading:11390438-Mice, Inbred C57BL,
pubmed-meshheading:11390438-Receptors, Interleukin-2,
pubmed-meshheading:11390438-T-Lymphocytes, Regulatory
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pubmed:year |
2001
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pubmed:articleTitle |
CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade.
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pubmed:affiliation |
University of Minnesota Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, 420 SE Delaware St., Minneapolis, MN 55455, USA.
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pubmed:publicationType |
Journal Article
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