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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2001-6-4
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pubmed:abstractText |
RME-1 is an Eps15-homology (EH)-domain protein that was identified in a genetic screen for endocytosis genes in Caenorhabditis elegans. When expressed in a CHO cell line, the worm RME-1 protein and a mouse homologue are both associated with the endocytic recycling compartment. Here we show that expression of a dominant-negative construct with a point mutation near the EH domain results in redistribution of the endocytic recycling compartment and slowing down of transferrin receptor recycling. The delivery of a TGN38 chimaeric protein to the trans-Golgi network is also slowed down. The function of Rme-1 in endocytic recycling is evolutionarily conserved in metazoans as shown by the protein's properties in C. elegans.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Eps15 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Furin,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Subtilisins,
http://linkedlifedata.com/resource/pubmed/chemical/Tgoln1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tgoln2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transferrin
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1465-7392
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
567-72
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11389441-Animals,
pubmed-meshheading:11389441-CHO Cells,
pubmed-meshheading:11389441-Caenorhabditis elegans Proteins,
pubmed-meshheading:11389441-Calcium-Binding Proteins,
pubmed-meshheading:11389441-Cell Compartmentation,
pubmed-meshheading:11389441-Cricetinae,
pubmed-meshheading:11389441-Furin,
pubmed-meshheading:11389441-Glycoproteins,
pubmed-meshheading:11389441-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:11389441-Membrane Glycoproteins,
pubmed-meshheading:11389441-Membrane Proteins,
pubmed-meshheading:11389441-Mice,
pubmed-meshheading:11389441-Mutation,
pubmed-meshheading:11389441-Phosphoproteins,
pubmed-meshheading:11389441-Protein Structure, Tertiary,
pubmed-meshheading:11389441-Subtilisins,
pubmed-meshheading:11389441-Transferrin,
pubmed-meshheading:11389441-Transport Vesicles
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pubmed:year |
2001
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pubmed:articleTitle |
Rme-1 regulates the distribution and function of the endocytic recycling compartment in mammalian cells.
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pubmed:affiliation |
Department of Biochemistry, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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