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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2001-5-31
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pubmed:abstractText |
Sonic hedgehog (Shh) is a prototypical morphogen known to regulate epithelial/mesenchymal interactions during embryonic development. We found that the hedgehog-signaling pathway is present in adult cardiovascular tissues and can be activated in vivo. Shh was able to induce robust angiogenesis, characterized by distinct large-diameter vessels. Shh also augmented blood-flow recovery and limb salvage following operatively induced hind-limb ischemia in aged mice. In vitro, Shh had no effect on endothelial-cell migration or proliferation; instead, it induced expression of two families of angiogenic cytokines, including all three vascular endothelial growth factor-1 isoforms and angiopoietins-1 and -2 from interstitial mesenchymal cells. These findings reveal a novel role for Shh as an indirect angiogenic factor regulating expression of multiple angiogenic cytokines and indicate that Shh might have potential therapeutic use for ischemic disorders.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiopoietin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Angiopoietin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Angpt1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelial Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Hedgehog Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SHH protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/patched receptors
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1078-8956
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pubmed:author |
pubmed-author:AsaharaTT,
pubmed-author:BakerD PDP,
pubmed-author:Blake PepinskyRR,
pubmed-author:CorbleyM JMJ,
pubmed-author:IsnerJ MJM,
pubmed-author:KearneyMM,
pubmed-author:LaneD GDG,
pubmed-author:PolaRR,
pubmed-author:ShapiroRR,
pubmed-author:SilverMM,
pubmed-author:TaylorF RFR
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
706-11
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pubmed:dateRevised |
2011-8-3
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pubmed:meshHeading |
pubmed-meshheading:11385508-Angiopoietin-1,
pubmed-meshheading:11385508-Angiopoietin-2,
pubmed-meshheading:11385508-Animals,
pubmed-meshheading:11385508-Blood Vessels,
pubmed-meshheading:11385508-Corneal Neovascularization,
pubmed-meshheading:11385508-Endothelial Growth Factors,
pubmed-meshheading:11385508-Female,
pubmed-meshheading:11385508-Genes, Reporter,
pubmed-meshheading:11385508-Hedgehog Proteins,
pubmed-meshheading:11385508-Hindlimb,
pubmed-meshheading:11385508-Humans,
pubmed-meshheading:11385508-Immunohistochemistry,
pubmed-meshheading:11385508-Ischemia,
pubmed-meshheading:11385508-Lymphokines,
pubmed-meshheading:11385508-Male,
pubmed-meshheading:11385508-Membrane Glycoproteins,
pubmed-meshheading:11385508-Membrane Proteins,
pubmed-meshheading:11385508-Mice,
pubmed-meshheading:11385508-Mice, Inbred C57BL,
pubmed-meshheading:11385508-Myocardium,
pubmed-meshheading:11385508-Neovascularization, Physiologic,
pubmed-meshheading:11385508-Proteins,
pubmed-meshheading:11385508-Receptors, Cell Surface,
pubmed-meshheading:11385508-Recombinant Fusion Proteins,
pubmed-meshheading:11385508-Regional Blood Flow,
pubmed-meshheading:11385508-Signal Transduction,
pubmed-meshheading:11385508-Trans-Activators,
pubmed-meshheading:11385508-Up-Regulation,
pubmed-meshheading:11385508-Vascular Endothelial Growth Factor A,
pubmed-meshheading:11385508-Vascular Endothelial Growth Factors
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pubmed:year |
2001
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pubmed:articleTitle |
The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors.
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pubmed:affiliation |
Department of Medicine, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA.
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pubmed:publicationType |
Journal Article
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