Linked Life Data

11380116

Source:http://linkedlifedata.com/resource/pubmed/id/11380116

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pubmed-article:11380116pubmed:abstractTextIt has been suggested that matrix metalloproteinase-3 (MMP-3, stromelysin-1) has an important role in the degeneration of intervertebral discs (IVDs). A human MMP-3 promoter 5A/6A polymorphism was reported to be involved in the regulation of MMP-3 gene expression. We suggest that IVD degeneration is associated with 5A/6A polymorphism. We studied 54 young and 49 elderly Japanese subjects. Degeneration of the lumbar discs was graded using MRI in the younger group and by radiography in the elderly. 5A/6A polymorphism was determined by polymerase-chain reaction-based assays. We found that the 5A5A and 5A6A genotype in the elderly was associated with a significantly larger number of degenerative IVDs than the 6A6A (p < 0.05), but there was no significant difference in the young. In the elderly, the IVD degenerative scores were also distributed more highly in the 5A5A and 5A6A genotypes (p = 0.0029). Our findings indicate that the 5A allele is a possible risk factor for the acceleration of degenerative changes in the lumbar disc in the elderly.lld:pubmed
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pubmed-article:11380116pubmed:dateRevised2010-11-10lld:pubmed
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pubmed-article:11380116pubmed:articleTitleThe association of degeneration of the intervertebral disc with 5a/6a polymorphism in the promoter of the human matrix metalloproteinase-3 gene.lld:pubmed
pubmed-article:11380116pubmed:affiliationDepartment of Frontier Surgical Therapeutics, Tokyo Medical and Dental University, Japan.lld:pubmed
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pubmed-article:11380116pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:11380116pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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