Source:http://linkedlifedata.com/resource/pubmed/id/11380116
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2001-5-29
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pubmed:abstractText |
It has been suggested that matrix metalloproteinase-3 (MMP-3, stromelysin-1) has an important role in the degeneration of intervertebral discs (IVDs). A human MMP-3 promoter 5A/6A polymorphism was reported to be involved in the regulation of MMP-3 gene expression. We suggest that IVD degeneration is associated with 5A/6A polymorphism. We studied 54 young and 49 elderly Japanese subjects. Degeneration of the lumbar discs was graded using MRI in the younger group and by radiography in the elderly. 5A/6A polymorphism was determined by polymerase-chain reaction-based assays. We found that the 5A5A and 5A6A genotype in the elderly was associated with a significantly larger number of degenerative IVDs than the 6A6A (p < 0.05), but there was no significant difference in the young. In the elderly, the IVD degenerative scores were also distributed more highly in the 5A5A and 5A6A genotypes (p = 0.0029). Our findings indicate that the 5A allele is a possible risk factor for the acceleration of degenerative changes in the lumbar disc in the elderly.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0301-620X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
491-5
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pubmed:dateRevised |
2010-11-10
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pubmed:meshHeading |
pubmed-meshheading:11380116-Adolescent,
pubmed-meshheading:11380116-Adult,
pubmed-meshheading:11380116-Aged,
pubmed-meshheading:11380116-Alleles,
pubmed-meshheading:11380116-Female,
pubmed-meshheading:11380116-Humans,
pubmed-meshheading:11380116-Lumbar Vertebrae,
pubmed-meshheading:11380116-Male,
pubmed-meshheading:11380116-Matrix Metalloproteinase 3,
pubmed-meshheading:11380116-Middle Aged,
pubmed-meshheading:11380116-Polymorphism, Genetic,
pubmed-meshheading:11380116-Spinal Diseases
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pubmed:year |
2001
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pubmed:articleTitle |
The association of degeneration of the intervertebral disc with 5a/6a polymorphism in the promoter of the human matrix metalloproteinase-3 gene.
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pubmed:affiliation |
Department of Frontier Surgical Therapeutics, Tokyo Medical and Dental University, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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