Linked Life Data

11378324

Source:http://linkedlifedata.com/resource/pubmed/id/11378324

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-5-29
pubmed:abstractText
Cyclosporin (CYA) is a therapeutic agent used in the treatment of psoriasis vulgaris. However, the effectiveness of CYA therapy varies among patients. In the present study, due to the fact that CYA mainly acts on lymphocytes, we hypothesized that a measurement of the sensitivity of lymphocytes to CYA in vitro (IC50) could be applied to patients with psoriasis vulgaris to determine therapeutic success. We measured IC50 levels of 32 patients presenting with psoriasis prior to CYA administration, and classified them into three groups according to IC50 levels: favorable, moderate and low sensitivity. CYA sensitivity levels were correlated with the degree of improvements in psoriasis area and severity index (PASI) scores, CYA dosage and occurrence of side-effects (hepatopathy and nephropathy). Results showed the degree of improvement in PASI scores differed significantly between the favorable and low sensitivity groups (P < 0.05). Furthermore, CYA dosage was lowest in the favorable sensitivity group and highest in the low sensitivity group. Moreover, hepatopathies and nephropathies were detected in the low and moderate sensitivity groups, but not in the favorable sensitivity group. These results suggest that the effectiveness of CYA therapy as a treatment of psoriasis vulgaris is affected by the sensitivity of lymphocytes in each patient.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0923-1811
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
94-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Relationship between lymphocyte cyclosporin sensitivity and clinical progress of psoriasis.
pubmed:affiliation
Department of Dermatology, Tokai University School of Medicine, Bohseidai, Isehara, 259-1193, Kanagawa, Japan.
pubmed:publicationType
Journal Article, In Vitro