rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2001-5-25
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pubmed:abstractText |
Pseudodestruxins A (1) and B (2), two new cyclic peptides, have been isolated from cultures of the coprophilous fungus Nigrosabulum globosum. The structure of pseudodestruxin A (1) was elucidated using 2D NMR techniques and confirmed by single-crystal X-ray diffraction analysis. The structure of 2 was assigned by comparing its NMR and FABMS data with those of compound 1. The known compounds ascochlorin and 5-chlorocollectorin B were also isolated from N. globosum. Although 1 and 2 display antibacterial effects, ascochlorin was found to be responsible for the antifungal activity of the crude extract.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0163-3864
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
555-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11374942-Amino Acids,
pubmed-meshheading:11374942-Anti-Bacterial Agents,
pubmed-meshheading:11374942-Anti-Infective Agents,
pubmed-meshheading:11374942-Ascomycota,
pubmed-meshheading:11374942-Bacteria,
pubmed-meshheading:11374942-Chromatography, High Pressure Liquid,
pubmed-meshheading:11374942-Chromatography, Thin Layer,
pubmed-meshheading:11374942-Crystallography, X-Ray,
pubmed-meshheading:11374942-Depsipeptides,
pubmed-meshheading:11374942-Fungal Proteins,
pubmed-meshheading:11374942-Hydrolysis,
pubmed-meshheading:11374942-Magnetic Resonance Spectroscopy,
pubmed-meshheading:11374942-Microbial Sensitivity Tests,
pubmed-meshheading:11374942-Peptides, Cyclic,
pubmed-meshheading:11374942-Spectrometry, Mass, Fast Atom Bombardment
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pubmed:year |
2001
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pubmed:articleTitle |
Pseudodestruxins A and B: new cyclic depsipeptides from the coprophilous fungus Nigrosabulum globosum.
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pubmed:affiliation |
Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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