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rdf:type |
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lifeskim:mentions |
umls-concept:C0007600,
umls-concept:C0017337,
umls-concept:C0024779,
umls-concept:C0036849,
umls-concept:C1366517,
umls-concept:C1421506,
umls-concept:C1442518,
umls-concept:C1512505,
umls-concept:C1521697,
umls-concept:C1552652,
umls-concept:C1552685,
umls-concept:C1705195
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pubmed:issue |
1
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pubmed:dateCreated |
2001-5-25
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pubmed:databankReference |
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pubmed:abstractText |
We describe the isolation and characterization of NSD3, the third member of a gene family including Nsd1 and NSD2. Murine Nsd1 was isolated in a search for proteins that interact with the ligand-binding domain of retinoic acid receptor alpha. NSD2 (also known as WHSC1 and MMSET) is located in the Wolf-Hirschhorn syndrome (WHS) critical region on 4p16.3 and is involved in multiple myeloma with t(4;14) translocations. The proteins Nsd1, NSD2, and NSD3 are highly similar within a block of about 700 amino acids. This block contains several conserved domains, such as the SET domain and the PHD finger, present in proteins involved in development and/or chromatin reorganization. The NSD3 gene consists of an 8.5-kb transcript composed of 23 coding exons and spans >90 kb of genomic DNA. NSD3 maps to chromosome band 8p12 and is amplified in several tumor cell lines and primary breast carcinomas.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0888-7543
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
79-88
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11374904-Alternative Splicing,
pubmed-meshheading:11374904-Amino Acid Sequence,
pubmed-meshheading:11374904-Binding Sites,
pubmed-meshheading:11374904-Blotting, Northern,
pubmed-meshheading:11374904-Breast Neoplasms,
pubmed-meshheading:11374904-Carrier Proteins,
pubmed-meshheading:11374904-Chromosome Mapping,
pubmed-meshheading:11374904-Chromosomes, Human, Pair 8,
pubmed-meshheading:11374904-Cloning, Molecular,
pubmed-meshheading:11374904-DNA, Complementary,
pubmed-meshheading:11374904-Exons,
pubmed-meshheading:11374904-Female,
pubmed-meshheading:11374904-Gene Amplification,
pubmed-meshheading:11374904-Gene Expression,
pubmed-meshheading:11374904-Genes,
pubmed-meshheading:11374904-Histone-Lysine N-Methyltransferase,
pubmed-meshheading:11374904-Humans,
pubmed-meshheading:11374904-In Situ Hybridization, Fluorescence,
pubmed-meshheading:11374904-Introns,
pubmed-meshheading:11374904-Molecular Sequence Data,
pubmed-meshheading:11374904-Nuclear Proteins,
pubmed-meshheading:11374904-Poly A,
pubmed-meshheading:11374904-Protein Isoforms,
pubmed-meshheading:11374904-RNA,
pubmed-meshheading:11374904-Sequence Alignment,
pubmed-meshheading:11374904-Sequence Analysis, DNA,
pubmed-meshheading:11374904-Sequence Homology, Amino Acid,
pubmed-meshheading:11374904-Tissue Distribution,
pubmed-meshheading:11374904-Tumor Cells, Cultured
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pubmed:year |
2001
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pubmed:articleTitle |
NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines.
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pubmed:affiliation |
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Illkirch Cedex, C.U. de Strasbourg, F-67404, France. angrand@igbmc.u-strasbg.fr
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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