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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2001-5-24
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pubmed:abstractText |
To enhance the stability in vivo, new derivatives of cytogenin were synthesized, and their biological activity and stability in mice were estimated. 2-(8-Hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl)propionic acid (NM-3) was found to be the most stable among them. It modified collagen-induced arthritis in mice. It also showed potent anti-angiogenic activity in a mouse dorsal air sac assay.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0021-8820
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
285-96
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11372785-Animals,
pubmed-meshheading:11372785-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:11372785-Antibiotics, Antineoplastic,
pubmed-meshheading:11372785-Arthritis,
pubmed-meshheading:11372785-Coumarins,
pubmed-meshheading:11372785-Drug Stability,
pubmed-meshheading:11372785-Isocoumarins,
pubmed-meshheading:11372785-Magnetic Resonance Spectroscopy,
pubmed-meshheading:11372785-Male,
pubmed-meshheading:11372785-Mice,
pubmed-meshheading:11372785-Mice, Inbred DBA,
pubmed-meshheading:11372785-Mice, Inbred ICR,
pubmed-meshheading:11372785-Neovascularization, Pathologic,
pubmed-meshheading:11372785-Rats,
pubmed-meshheading:11372785-Rats, Sprague-Dawley,
pubmed-meshheading:11372785-Spectrophotometry, Ultraviolet,
pubmed-meshheading:11372785-Spectroscopy, Fourier Transform Infrared
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pubmed:year |
2001
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pubmed:articleTitle |
Synthesis and biological evaluation of cytogenin derivatives.
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pubmed:affiliation |
Central Research Laboratories, Mercian Corp, Johnan, Fujisawa, Japan. n-matsumoto@hkg.odn.ne.jp
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pubmed:publicationType |
Journal Article,
In Vitro
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