rdf:type |
|
lifeskim:mentions |
umls-concept:C0005682,
umls-concept:C0015350,
umls-concept:C0017337,
umls-concept:C0026336,
umls-concept:C0175677,
umls-concept:C0205314,
umls-concept:C0679622,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2348480,
umls-concept:C2911692
|
pubmed:issue |
6 Pt 2
|
pubmed:dateCreated |
2001-5-23
|
pubmed:abstractText |
Congenital bladder outlet obstruction from either mechanical or functional causes often results in clinical bladder fibrosis. We tested the hypothesis that early molecular changes relevant to fibrosis occur in response to stretch injury of the bladder wall and that specific extracellular matrix receptors mediate some of these responses. Furthermore, we introduce a novel ex vivo model of bladder injury which has advantages over previously described in vivo bladder outlet obstruction models by uniquely interrogating molecular responses to bladder distention.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0022-5347
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
165
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
2235-40
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:11371952-Animals,
pubmed-meshheading:11371952-Antigens, CD44,
pubmed-meshheading:11371952-Collagen,
pubmed-meshheading:11371952-Extracellular Matrix Proteins,
pubmed-meshheading:11371952-Hyaluronic Acid,
pubmed-meshheading:11371952-Male,
pubmed-meshheading:11371952-Models, Animal,
pubmed-meshheading:11371952-Muscle, Smooth,
pubmed-meshheading:11371952-Muscle Contraction,
pubmed-meshheading:11371952-RNA, Messenger,
pubmed-meshheading:11371952-Rats,
pubmed-meshheading:11371952-Rats, Sprague-Dawley,
pubmed-meshheading:11371952-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:11371952-Urinary Bladder,
pubmed-meshheading:11371952-Urodynamics
|
pubmed:year |
2001
|
pubmed:articleTitle |
Extracellular matrix gene responses in a novel ex vivo model of bladder stretch injury.
|
pubmed:affiliation |
Divisions of Urology and Surgical Research, Hospital for Sick Children Research Institute and University of Toronto, Toronto, Ontario, Canada.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|