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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6 Pt 1
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pubmed:dateCreated |
2001-5-23
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pubmed:abstractText |
In the human prostate cancer cell lines LNCaP, DU145 and PC3, 27 primary prostate cancers, 10 benign prostatic hyperplasia specimens and 5 normal prostates we investigated the expression pattern of PAX2, a member of the PAX family of developmental control genes. PAX2 is expressed at high levels in developing undifferentiated cells of the urogenital system and is repressed upon terminal differentiation with no expression in normal adult cells. It is also been shown to be a proto-oncogene in mice and is expressed in human renal cell carcinoma.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-5347
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
165
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2115-20
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11371938-Blotting, Western,
pubmed-meshheading:11371938-DNA-Binding Proteins,
pubmed-meshheading:11371938-Fluorescent Antibody Technique,
pubmed-meshheading:11371938-Genes, Neoplasm,
pubmed-meshheading:11371938-Humans,
pubmed-meshheading:11371938-Male,
pubmed-meshheading:11371938-PAX2 Transcription Factor,
pubmed-meshheading:11371938-Prostatic Hyperplasia,
pubmed-meshheading:11371938-Prostatic Neoplasms,
pubmed-meshheading:11371938-RNA, Messenger,
pubmed-meshheading:11371938-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:11371938-Transcription Factors,
pubmed-meshheading:11371938-Tumor Cells, Cultured
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pubmed:year |
2001
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pubmed:articleTitle |
Expression of the developmental and oncogenic PAX2 gene in human prostate cancer.
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pubmed:affiliation |
Academic Unit of Medical and Community Genetics, Imperial College of Science Technology and Medicine, Kennedy-Galton Centre, Northwick Park Hospital, London, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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