Source:http://linkedlifedata.com/resource/pubmed/id/11368149
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2001-5-22
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pubmed:abstractText |
Glioblastoma cells produce cytokines with proinflammatory or immunosuppressive properties, or both, which, in addition to altered p53 gene expression, have been shown to be associated with glioblastoma resistance to radiotherapy. The reported data concerning cytokines have been isolated and sometimes discordant, and a comprehensive profile analysis of cytokines and their corresponding receptors in irradiated glioblastomas has received limited attention. The object of this study was to test the hypothesis that radiation alone in clinically relevant doses would not significantly alter expression of endogenous cytokines and their receptors in human glioblastoma celll ines with wild-type and mutant p53.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0147-958X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
76-82
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:11368149-Cobalt Radioisotopes,
pubmed-meshheading:11368149-Cytokines,
pubmed-meshheading:11368149-Flow Cytometry,
pubmed-meshheading:11368149-Gamma Rays,
pubmed-meshheading:11368149-Gene Expression,
pubmed-meshheading:11368149-Genes, p53,
pubmed-meshheading:11368149-Glioblastoma,
pubmed-meshheading:11368149-Humans,
pubmed-meshheading:11368149-Mutation,
pubmed-meshheading:11368149-RNA, Messenger,
pubmed-meshheading:11368149-Radiation Tolerance,
pubmed-meshheading:11368149-Receptors, Cytokine,
pubmed-meshheading:11368149-Tumor Cells, Cultured
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pubmed:year |
2001
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pubmed:articleTitle |
Effect of radiation on cytokine and cytokine receptor messenger-RNA profiles in p53 wild and mutated human glioblastoma cell lines.
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pubmed:affiliation |
Department of Oncology, Cross Cancer Institute/University of Alberta, Edmonton.
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pubmed:publicationType |
Journal Article
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