Linked Life Data

11360554

Source:http://linkedlifedata.com/resource/pubmed/id/11360554

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2001-5-21
pubmed:abstractText
To evaluate the change of perioperative cell mediated immunity after cardiac operation with cardiopulmonary bypass (CPB), so as to provide some information for timely prevention and treatment against postoperative immunological disorder, 40 patients were studied. By searching for the effects of CPB and anesthesia, interleukin-2 receptor (IL-2R) expression upon the surface of peripheral blood mononuclear cells (PBMC), as well as interleukin-2 (IL-2) production in vitro was traced 55 min after anesthesia, at end of CPB, on postoperative 1, 7, and 14 day versus preanesthesia control. Our data demonstrated that expression of IL-2R on PBMC was significantly suppressed in all comparing with the baseline value, meanwhile, IL-2 production in vitro also statistically dropped. However, no statistical difference was found on perioperative IL-2R expression and IL-2 synthesis in the cholecystectomy group. We conclude that postoperative immunological disorder seems to be the main factor, which could be denoted as reduced IL-2R expression on PBMC and IL-2 synthesis in vitro for sepsis, even multiple system organ failure developed after cardiac surgery.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1001-9294
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
220-3
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Changes on receptor expression and production of interleukin-2 in circulating lymphocyte population after open heart surgery.
pubmed:affiliation
Department of Anesthesiology, Tongji Hospital, Tongji Medical University, Wuhan 430030.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't