Aim was to compare the effects of estradiol-only therapy with combined estradiol/progestin treatment on the excretion of vasoactive mediators surrogating on possible effects in the vascular system. The progestin used was dienogest, a new C19-progestin with antiandrogenic properties.
Section of Endocrinology and Menopause, Department of Obstetrics and Gynecology, University Hospital, University of Tuebingen, Schleichstrasse 4, 72 076, Tuebingen, Germany. endo.meno@med.uni-tuebingen.de